Targeted Therapy

Question 1

Does Crizotinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 1

both

Question 2

Does alectinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 2

hepatic

Question 3

Does brigatinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 3

both

Question 4

Does lorlatinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 4

None

Question 5

ALK inhibitor that has highest incidence of pneumonitis

Answer 5

brigatinib

Question 6

ALK inhibitor with highest incidence of visual disturbance

Answer 6

crizotinib

Question 7

Drug class that has bradycardia, pneumonitis, N/V, visual disturbance, diarrhea

Answer 7

ALK inhibitors

Question 8

Black box warnings for IV VEGF mAbs (3)

Answer 8

Bleeding
Wound healing complications
GI perf

Question 9

Sorafenib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 9

Renal

Question 10

Does axitinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 10

hepatic

Question 11

Does cabozantinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 11

hepatic

Question 12

What drug class has these SEs? Bleeding, impaired wound healing, Nephrotic syndrome, PRES, GI perforation, Thyroiditis, Arthralgias, hand-foot, hepatotoxicity

Answer 12

VEGF TKIs

Question 13

What two VEGF TKIs have hair color changing

Answer 13

pazopanib
Cabozantinib

Question 14

Which VEGF TKI increases INR

Answer 14

regorafenib

Question 15

Does cetuximab need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 15

none

Question 16

Does osimertinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 16

none

Question 17

Which class has these AEs? Diarrhea, paronychia, rash, xeroderma, LFTs, pneumonitis

Answer 17

EGFR TKIs

Question 18

What are three class effects of EGFR TKIs?

Answer 18

Diarrhea
Paronychia
Rash

Question 19

Does trastuzumab need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 19

none

Question 20

Does pertuzumab need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 20

None

Question 21

Does enhertu need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 21

none

Question 22

Does TDM1 need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 22

None

Question 23

Class effect of anti-HER2 (2)

Answer 23

Cardiomyopathy
Diarrhea

Question 24

Which drug class has these effects? Fatigue, CPK increase, dysgeusia, muscle spasm, arthralgia

Answer 24

Hedgehog inhibitors

Question 25

Does everolimus need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 25

Hepatic

Question 26

Monitoring needed while on everolimus (3)

Answer 26

Urinary protein A1c FLP

Question 27

Which class has this AE profile? Edema, dyslipidemia, hyperglycemia, stomatitis, LFTs

Answer 27

mTOR inhibitors

Question 28

Does olaparib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 28

Renal

Question 29

Which class has this AE profile? N/V, anemia, neutropenia, thrombpcytopenia, fatigue, MDS/AML warning

Answer 29

PAPR inhibitors

Question 30

Which class has this AE profile? Hyperphos, onycholysis, xerodermia, Retinal pigment epithelium detachment.

Answer 30

FGFR inhibitors

Question 31

Which class has this AE profile? CNS toxicity, LFTs, edema, fatigue, arthralgia, bone fracture

Answer 31

NTRK inhibitors

Question 32

Which class has this AE profile? Pyrexia, arthralgia, QT prolongation, LFTs, cardiomyopathy

Answer 32

BRAK/MEK inhihitors

Question 33

Do the CDK4/6 inhibitors need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 33

Hepatic Ribo needs dose reduction for renal dysfunction

Question 34

MoA avapritinib

Answer 34

PDGFR inhibitor

Question 35

MoA ripretinib

Answer 35

PDGFR inhibitors

Question 36

What class has these AEs? Peripheral edema, dyspnea, increased Cr, L:FTs, pyrexia, lymphocytopenia, hyponia

Answer 36

MET inhibitors

Question 37

MoA Selpercatinib

Answer 37

RET inhibitor

Question 38

MoA Pralsetinib

Answer 38

RET inhibitor

Question 39

What class has this AE profile? Diarrhea, LFTs, MSK pain, cardiotoxic, edema, pneumonitis

Answer 39

KRAS inhibitors

Question 40

MoA Enfortumab vedotin

Answer 40

Anti-Nectin 4 ADC

Question 41

When to hold HER2 directed therapy for LVEF?

Answer 41

16% or more drop in EF from baseline OR if EF 10% decrease