Heme Targeted Therapy

Question 1

Target of Daratumumab

Answer 1

CD38

Question 2

Target of ELotuzumab

Answer 2

SLAMF7

Question 3

Target of Brentuximab vedotin

Answer 3

CD30

Question 4

Target of polatuzumab vedotinq

Answer 4

CD79b

Question 5

Target of Gemtuzumab ozogamicin

Answer 5

Cd33

Question 6

Target of inotuzumab ozogamicin

Answer 6

CD22

Question 7

Target of Loncastuximab tesirine

Answer 7

D19

Question 8

Target of tafasitamab

Answer 8

CD19

Question 9

Target of Mogamulizumab

Answer 9

CCR4

Question 10

Black box warnings of Rituximab (4)

Answer 10

HBV react
PML
Infusion reaction
severe mucocutaneous reactions

Question 11

What prophylactic medication is necessary to give during Daratumumab therapy?

Answer 11

VZV prophylaxis

Question 12

Daratumumab interferes with what other hematology-related test?

Answer 12

DAT

Question 13

Prophy required for Polatuzumab therapy

Answer 13

PCP and HSV

Question 14

Black box warning for gemtuzumab

Answer 14

Hepatotoxic/VOD

Question 15

Black box warning for inotuzumab

Answer 15

Hepatotoxic/VOD
Higher 100 day post-transplant mortality

Question 16

Which BCR/ABL TKI has highest incidence of diarrhea?

Answer 16

Bosutinib

Question 17

Which BCR/ABL has highest incidence of pleural effusions?

Answer 17

Dasatinib

Question 18

Which BCR/ABL TKI has highest incidence of edema?

Answer 18

Imatinib

Question 19

Does bortezomib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 19

Hepatic

Question 20

Does Carfilzomib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 20

Hepatic

Question 21

Does ixazomib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 21

Both

Question 22

What prophy medication is needed for all patients treated with a proteasome inhibitor?

Answer 22

HSV prophy (acy, valacy, famci)

Question 23

MoA Vorinostat

Answer 23

HDAC inhibitor

Question 24

MoA Romidepsin

Answer 24

HDAC inhibitor

Question 25

MoA Belinostat

Answer 25

HDAC inhibitor

Question 26

Class side effect of QTC prolongation, hyperglycemia, thromboembolism, infection

Answer 26

HDAC inhibitors

Question 27

Does ibrutinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 27

Hepatic

Question 28

Does acalabrutinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 28

Neither

Question 29

Does zanubrutinib need adjustment for renal dysfunction, hepatic dysfunction, both, or neither?

Answer 29

Severe hepatic

Question 30

Which BTK inhibitor has least AFIb?

Answer 30

Zanubrutinib

Question 31

AEs of midostaurin (6)

Answer 31

Increased SCr Mucositis Diarrhea Prolonged QT MSK pain Arthralgia

Question 32

3 AEs of Gilteritinib

Answer 32

Differentiation syndrome prolonged QT Pancreatitis

Question 33

Common side effect of IDH inhibitors?

Answer 33

Differentiation syndrome