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DT1 Exam 2 > Targeted Review > Flashcards

Targeted Review Flashcards

1
Q

percutaneous absorption is

A

exclusively diffusion

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2
Q

rate limiting step of percutaneous absorption

A

permeation through stratum corneum

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3
Q

ways to decrease amount of drug in receptor phase

A

increase thickness

decrease drug penetration

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4
Q

absent in thin skin

A

stratum lucidum

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5
Q

tumors in epiphysis

A

chondroblastoma

clear cell chondrosarcoma

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6
Q

tumors in diaphysis

A

Ewing sarcoma

fibrous dysplasia

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7
Q

tumors of metaphysis and epiphysis

A

giant cell tumor

aneurysmal bone cysts

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8
Q

RANKL/RANK pathway slides 5-7

A

OPG decoy receptor that binds to RNAKL and osteoprotects

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9
Q

bone that resists force in all directions

A

woven

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10
Q

bone shouldn’t be seen in adults slides 11-13

A

woven

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11
Q

replaces woven bone

A

lamellar

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12
Q

genetic cause of achondroplasia

A

GOF in FGFR3

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13
Q

causes of osteopetrosis slide 29

A

ca2 deficiency
LRP5 GOF
RANKL defect
marble bone disease

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14
Q

hat doesn’t fit as well

A

Paget

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15
Q

slide 90

A

Pott’s disease

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16
Q

saber shin and saddle nose

A

syphilis

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17
Q

osteoma associations

A

intestinal polyps, epidermal cysts, multiple osteomas, fibromatosis

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18
Q

small and relieved by NSAIDs

A

osteoid osteomas

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19
Q

big and not relieved by NSAIDs

A

osteoblastomas

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20
Q

Codman’s triangle slide 21

A

osteosarcoma

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21
Q

most common form of skeletal malignancy

A

metastatic disease

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22
Q

Herringbone pattern

A

fibrosarcoma

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23
Q

intramuscular lipoma

A

slide 22

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24
Q

APC/beta catenin association

A

desmoid tumors

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25
Q

embryonal rhabdomyosarcoma

A

slide 58/59

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26
Q

cause of myasthenia gravis

A

antibody against acteylcholine receptor

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27
Q

most common bone tumor in kids

A

fibrous cortical defect

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28
Q

chicken wire pattern

A

liposarcoma myxoid/round cell

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29
Q

location of CPPD

A

knee

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30
Q

location of gout

A

toe

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31
Q

cause of malignant hyperthermia

A

ryanodine receptor

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32
Q

reverse malignant hyperthermia

A

dantrolene

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33
Q

difference between myasthenia gravis and Lambert Eaton

A

MG worse with activity

LES improves with activity

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34
Q

endocrinopathy and polyostotic fibrous dysplasia

A

McCune Albright

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35
Q

targetoid lesion in 2yo with painful finger

A

osteoid osteoma

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36
Q

metastatic/scalloping appearance in soft tissue

A

liposarcoma

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37
Q

not painful, most common incidental tumor finding

A

enchondroma

38
Q

jigsaw puzzle appearance

A

enchondroma

39
Q

African with back pain and cough, test for

A

tuberculosis-Pott disease

tuberculin skin test

40
Q

myogenin positive marker

A

embryonic rhabdomyosarcoma

41
Q

cytokeratin positive marker

A

synovial sarcoma

42
Q

short stature, wormian bone, supernumerary teeth

A

cleidocranial dysplasia

43
Q

jaw drooping face

A

myotonic dystrophy

44
Q

associated with small vessel vasculitis

A

dermatomyostitis

45
Q

Gowers sign

A

using hands to get up

46
Q

biphasic pattern

A

synovial sarcoma

47
Q

translocation in synovial sarcoma

A

x;18

48
Q

blade grass appearance

A

Paget disease

49
Q

painless subcutaneous mass

A

lipoma on back

50
Q

narrow fingers cause

A

parathyroid adenoma

51
Q

28 yo with prior C sections and big abdominal wall mass

A

abdominal wall fibromatosis

52
Q

28 yo with prior C sections and big abdominal wall mass

A

abdominal wall fibromatosis

53
Q

diff pityriasis versicolor

A

wood lamp

54
Q

diff for tinea nigra

A

melanoma

traumatic inoculation

55
Q

dermatophytes

A

trichophyton
epidermophyton
microsporum

56
Q

Rose Gardner’s disease

A

sporotrichosis schenckii

57
Q

lab findings of s. schenckii

A

cigar shaped

asteroid bodies

58
Q

cauliflower with sclerotic and medlar bodies

A

chromoblastomycosis

59
Q

umbilicated papule

A

molluscum

60
Q

dewdrop on rose petal

A

HSV

61
Q

lesions at different stages

A

chickenpox

62
Q

respiratory spread

A

VSV

63
Q

high fever often causing seizures

A

Roseola infantum

64
Q

cough, coryza, conjunctivitis, Koplik spots

A

measles

65
Q

blueberry muffin from EMH, cataracts, PDA, microcephaly

A

rubeola

66
Q

replicates in erythroid precursors, causes slapped cheek

A

parvoB19

67
Q

lesions same age

A

smallpox

68
Q

DOC rickettsia and orientia

A

doxy

69
Q

no beta lactams

A

rickettsia

70
Q

centripetal rash, ixodes tick

A

RMSF

71
Q

eschars of rickettsial pox

A

R. akari

diff from anthrax

72
Q

flying squirrels

A

R. prowazekii

73
Q

Erlichia vs anaplasma

A

erlichia-morula, SE/MW

anaplasma-no morula, more northern

74
Q

spirochetes

A

borrelia

75
Q

lyme treatment

A

over 8 docy

under 8 amoxicillin/cefuroxime

76
Q

no arthritis/neuro/chronic diseases

A

STARI

77
Q

protazoa, may coinfect with lyme

A

babesia

78
Q

common after natural disasters

A

borrelia recurrentis

79
Q

interferes with MT

A

colchicine

80
Q

interferes with hematopoiesis causing agranulocytosis and aplastic anemia

A

colchicine

81
Q

allopurinol at diff concentrations

A

low-competitive

high-noncompetitive

82
Q

drugs that can cause acute gout

A

allopurinol/febuxostat

treat with colchicine or NSAID

83
Q

increase rate of MI/stroke

A

febuxostat

84
Q

converts uric acid into allotoin

A

rasburicase

85
Q

increases urate excretion which can cause renal stones or acute gout attack

A

probenecid

86
Q

decrease urate secretion

A

aspirin

87
Q

serum sickness causes

A

antivenoms and cefaclor

88
Q

Jarisch-Hexheimer reaction

A

flu like rxn from killing bacteria/spirochetes reeasing endotoxins

89
Q

causes Lupus reaction

A

sulfa, hydralazine, isoniazid, procainamide, phenytoin, etanercept (SHIPPE)

90
Q

causes eosinophilia

A

digitalis and ABX

91
Q

fibrotic lung causes

A

nitrofurantoin and bleomycin

92
Q

sandpaper rash

A

vasculitis

DT1 Exam 2 (6 decks)

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