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DT1 Exam 2 > Targeted Review > Flashcards

Targeted Review Flashcards

1
Q

percutaneous absorption is

A

exclusively diffusion

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2
Q

rate limiting step of percutaneous absorption

A

permeation through stratum corneum

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3
Q

ways to decrease amount of drug in receptor phase

A

increase thickness

decrease drug penetration

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4
Q

absent in thin skin

A

stratum lucidum

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5
Q

tumors in epiphysis

A

chondroblastoma

clear cell chondrosarcoma

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6
Q

tumors in diaphysis

A

Ewing sarcoma

fibrous dysplasia

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7
Q

tumors of metaphysis and epiphysis

A

giant cell tumor

aneurysmal bone cysts

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8
Q

RANKL/RANK pathway slides 5-7

A

OPG decoy receptor that binds to RNAKL and osteoprotects

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9
Q

bone that resists force in all directions

A

woven

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10
Q

bone shouldn’t be seen in adults slides 11-13

A

woven

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11
Q

replaces woven bone

A

lamellar

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12
Q

genetic cause of achondroplasia

A

GOF in FGFR3

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13
Q

causes of osteopetrosis slide 29

A

ca2 deficiency
LRP5 GOF
RANKL defect
marble bone disease

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14
Q

hat doesn’t fit as well

A

Paget

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15
Q

slide 90

A

Pott’s disease

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16
Q

saber shin and saddle nose

A

syphilis

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17
Q

osteoma associations

A

intestinal polyps, epidermal cysts, multiple osteomas, fibromatosis

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18
Q

small and relieved by NSAIDs

A

osteoid osteomas

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19
Q

big and not relieved by NSAIDs

A

osteoblastomas

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20
Q

Codman’s triangle slide 21

A

osteosarcoma

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21
Q

most common form of skeletal malignancy

A

metastatic disease

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22
Q

Herringbone pattern

A

fibrosarcoma

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23
Q

intramuscular lipoma

A

slide 22

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24
Q

APC/beta catenin association

A

desmoid tumors

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25
embryonal rhabdomyosarcoma
slide 58/59
26
cause of myasthenia gravis
antibody against acteylcholine receptor
27
most common bone tumor in kids
fibrous cortical defect
28
chicken wire pattern
liposarcoma myxoid/round cell
29
location of CPPD
knee
30
location of gout
toe
31
cause of malignant hyperthermia
ryanodine receptor
32
reverse malignant hyperthermia
dantrolene
33
difference between myasthenia gravis and Lambert Eaton
MG worse with activity | LES improves with activity
34
endocrinopathy and polyostotic fibrous dysplasia
McCune Albright
35
targetoid lesion in 2yo with painful finger
osteoid osteoma
36
metastatic/scalloping appearance in soft tissue
liposarcoma
37
not painful, most common incidental tumor finding
enchondroma
38
jigsaw puzzle appearance
enchondroma
39
African with back pain and cough, test for
tuberculosis-Pott disease | tuberculin skin test
40
myogenin positive marker
embryonic rhabdomyosarcoma
41
cytokeratin positive marker
synovial sarcoma
42
short stature, wormian bone, supernumerary teeth
cleidocranial dysplasia
43
jaw drooping face
myotonic dystrophy
44
associated with small vessel vasculitis
dermatomyostitis
45
Gowers sign
using hands to get up
46
biphasic pattern
synovial sarcoma
47
translocation in synovial sarcoma
x;18
48
blade grass appearance
Paget disease
49
painless subcutaneous mass
lipoma on back
50
narrow fingers cause
parathyroid adenoma
51
28 yo with prior C sections and big abdominal wall mass
abdominal wall fibromatosis
52
28 yo with prior C sections and big abdominal wall mass
abdominal wall fibromatosis
53
diff pityriasis versicolor
wood lamp
54
diff for tinea nigra
melanoma | traumatic inoculation
55
dermatophytes
trichophyton epidermophyton microsporum
56
Rose Gardner's disease
sporotrichosis schenckii
57
lab findings of s. schenckii
cigar shaped | asteroid bodies
58
cauliflower with sclerotic and medlar bodies
chromoblastomycosis
59
umbilicated papule
molluscum
60
dewdrop on rose petal
HSV
61
lesions at different stages
chickenpox
62
respiratory spread
VSV
63
high fever often causing seizures
Roseola infantum
64
cough, coryza, conjunctivitis, Koplik spots
measles
65
blueberry muffin from EMH, cataracts, PDA, microcephaly
rubeola
66
replicates in erythroid precursors, causes slapped cheek
parvoB19
67
lesions same age
smallpox
68
DOC rickettsia and orientia
doxy
69
no beta lactams
rickettsia
70
centripetal rash, ixodes tick
RMSF
71
eschars of rickettsial pox
R. akari | diff from anthrax
72
flying squirrels
R. prowazekii
73
Erlichia vs anaplasma
erlichia-morula, SE/MW | anaplasma-no morula, more northern
74
spirochetes
borrelia
75
lyme treatment
over 8 docy | under 8 amoxicillin/cefuroxime
76
no arthritis/neuro/chronic diseases
STARI
77
protazoa, may coinfect with lyme
babesia
78
common after natural disasters
borrelia recurrentis
79
interferes with MT
colchicine
80
interferes with hematopoiesis causing agranulocytosis and aplastic anemia
colchicine
81
allopurinol at diff concentrations
low-competitive | high-noncompetitive
82
drugs that can cause acute gout
allopurinol/febuxostat | treat with colchicine or NSAID
83
increase rate of MI/stroke
febuxostat
84
converts uric acid into allotoin
rasburicase
85
increases urate excretion which can cause renal stones or acute gout attack
probenecid
86
decrease urate secretion
aspirin
87
serum sickness causes
antivenoms and cefaclor
88
Jarisch-Hexheimer reaction
flu like rxn from killing bacteria/spirochetes reeasing endotoxins
89
causes Lupus reaction
sulfa, hydralazine, isoniazid, procainamide, phenytoin, etanercept (SHIPPE)
90
causes eosinophilia
digitalis and ABX
91
fibrotic lung causes
nitrofurantoin and bleomycin
92
sandpaper rash
vasculitis

DT1 Exam 2 (6 decks)

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