Targeted Cancer Drugs Flashcards
What drug targets VEGF?
Bevacizumab
What drugs target EGFR?
Cetuximab and Panitumumab
What drugs targets CD20?
Rituximab and Ofatumumab
What drug targets HER-2?
Trastuzumab
What drug targets CTLA-4?
Ipilimumab
What drug targets 26-S proteosome inhibitor?
Bortezomib
What type of drug is Bortezomib?
small molecule inhibitor (“ib” ending)
What are the indications for bevacizumab?
colorectal cancer
non small cell lung cancer
What are the indications for cetuximab?
colorectal cancer
head and neck cancer
What are the indications for panitumumab?
colorectal cancer
What are the indications for rituximab?
chronic lymphocytic leukemia
non-Hodgkin’s lymphoma
What are the indications for trastuzumab?
breast cancer
What are the indications for ipilimumab?
melanoma
What are the indications for ofatumumab?
chronic lymphocytic leukemia
What are the indications for bortezomib?
multiple myeloma
What oncogene is a growth factor receptor commonly found in glioblastoma, lung, and breast cancer?
EGFR/HER1
What oncogene is a growth factor receptor commonly found in breast, ovarian, and gastric cancer?
HER2/Neu
What oncogene functions as a G protein (signal transduciton) and is commonly found in multiple tumor types?
K-Ras
also N- and H-Ras
What oncogene functions in signal transduciton and is commonly found in multiple tumor types (and melanomas)?
B-Raf
What is the MOA of trastuzumab?
Apoptosis, ADCC
What are the toxicities associated with trastuzumab?
Cardiomyopathy
Infusion Reaction
What is the MOA of cetuximab?
Apoptosis, ADCC