Target DDS FINAL Flashcards
Who proposed the concept of drug targeting as a “Magic Bullet”?
Paul Ehrlich.
What are the two main components of drug targeting?
1) A component that recognizes and binds the target.
2) A component that provides therapeutic action.
What is drug targeting?
The ability of a drug to accumulate selectively and quantitatively in a target organ or tissue, ideally with high concentration at the disease site and minimal concentration in non-target areas.
What three components are currently coordinated in the concept of a magic bullet?
1) drug 2) targeting moiety 3) drug carrier.
Name some examples of targeting moieties.
Antibodies, lectins, lipoproteins, hormones, charged molecules, polysaccharides, low-molecular weight ligands.
What is a drug carrier?
A device or vector that transports drugs effectively to the target area, including polymers, nanoparticles, liposomes, and cells.
How can drug targeting be achieved?
Direct application, passive accumulation through leaky vasculature, physical targeting based on pH/temperature, magnetic targeting, chemical delivery systems, and antibody-directed delivery.
What is an example of direct application of a drug?
Intra-articular administration of hormonal drugs for arthritis.
Describe how drug accumulation occurs in leaky areas.
Increased vascular permeability allows drugs in carriers like liposomes and micelles to extravasate and accumulate in areas such as tumors and inflamed tissues.
What is physical targeting of drugs based on?
Abnormal pH and/or temperature in pathological areas compared to normal tissues.
What is magnetic targeting of drugs?
A method where drugs are immobilized on ferromagnetic carriers that accumulate in a specific area when an external magnetic field is applied.
Define prodrugs.
Pharmacologically inactive drug derivatives that are converted to active forms in vivo.
What is the purpose of polymer drug delivery systems?
To prolong the half-life of drugs and reduce toxicity, such as cardiotoxicity associated with daunorubicin.
How are antibody-drug conjugates utilized in targeted therapy?
They chemically link drugs to monoclonal antibodies that target tumor-associated antigens for precise delivery.
What is ADEPT (Antibody Directed Enzyme Prodrug Therapy)?
A two-step targeting system using an antibody-enzyme conjugate to selectively convert a non-toxic prodrug into an active drug at a tumor site.