Concepts of preformulation

Question 1

T/F: The physicochemical characterization of a drug and excipients are conducted during the pre-formulation studies.

Answer 1

false

Question 2

T/F: Drug dissolution is NOT necessary before drug adsorption.

Answer 2

false

Question 3

Name the solvent used as a lipophilic solvent.

Answer 3

n-octonol

Question 4

Name a solvent used as a hydrophilic solvent.

Answer 4

water

Question 5

_____ are molecules that are held close together with very little freedom of motion.

Answer 5

Solids

Question 6

T/F: Particle size is directly proportional to specific surface area.

Answer 6

false

Question 7

Which preformulation factors affects drug absorption, bioavailability, and dosage form stability?

Answer 7

particle size

Question 8

Which of the following particle shape has the minimum surface area?

Answer 8

sphere

Question 9

Melting point depression is useful in determining _____.

Answer 9

drug-excipient compatibility

Question 10

What parameter is useful in determining a drug’s ability to penetrate biological membrane?

Answer 10

partition coefficient, permeability, ionization

Question 11

What is the first step in drug bioavailability from a tablet?

Answer 11

disintegration

Question 12

T/F: Since polymorphs of a drug have the same chemical structure, they exhibit the same physiochemical properties.

Answer 12

false