TAKE 2 Flashcards
What is primary depression?
Depression not caused by any other illness
What is secondary depression?
Depression that occurs as a result of physical illness, or a medication or other non-mood mental illness
- i.e. cancer
What is major depressive disorder?
Clinical depression
Hospitalized
What are the symptoms of major depressive disorder?
How long do they last?
2 weeks
Depressed mood: hopeless, empty
Anhedonia: no joy
Appetite changes
Weight loss/gain
Insomnia
Fatigue
Constipation
Feelings of worthlessness/ guilt
Difficulty concentrating
SI (suicidal ideation)
Unable to function
May have psychosis; hallucinations/ delusions
Anorexia (poor appetite)
What is persistent depressive disorder?
Dysthymia
- Usually not hospitalized
What are the signs and symptoms of persistent depressive disorder?
How long do they last?
2 years
Think: Eeyore from Winnie the Pooh:
s/s becomes almost like their personality; it’s “the way they are”
s/s less severe
Overeating/ overweight
What are the phases of depression?
Acute
Continuation
Maintenance
Describe the acute phase of depression
Severe clinical signs in 6-8 weeks; high suicide risk
Goal: remission of symptoms
- Use of medication, therapy, psychotherapy, etc. to restore function
Describe the continuation phase of depression
Increased ability to function
Goal: prevent relapse
- Medication compliance
Describe the maintenance phase of depression
6-12 months
Goal: prevent reoccurrence of depression/maintenance of function
- Continue medication compliance for additional 12 months after showing signs of improvement
Assessment Guidelines for depression
risk of suicide or harm to others
Is depression primary or secondary
Hx of depression
Triggering events; what led to hospitalization
Support systems
Psychosocial/ Spiritual assessment
How do you assess for depression?
What is the Highest priority assessment?
Highest priority: risk of SI/HI
SIGECAPS: s/s of depression
S: Sleeping disturbances/ Sad mood: sleep too much/ too little
I: Interest diminished: apathy
G: Guilt in feeling: feelings of worthlessness
E: Energy decrease/ Esteem loss: anergia
C: Concentration diminished/ indecisiveness
A: Appetite changes: eat too much/ too little
P: Psychomotor retardation: slowing of movements/ agitation
S: SI
The highest likelihood of suicide occurs when
6-9 months after initial episode of depression
Depression assessment:
mood and affect
Anxiety
worthlessness
guilt
hopelessness/helplessness
anger
irritability
May not make eye contact
flat affect
Depression assessment:
Speech
poverty of speech; alogia;
volume low
Monotone speech
more time required to respond
Depression assessment:
thought Content and processes
Slow thinking/ delayed responses
rumination (thinking a thought over and over) on faults
indecisiveness
delusional thinking
negative automatic thoughts
Depression assessment:
Physical S/S
Anergia (lack of energy)
psychomotor retardation
psychomotor agitation
Decreased sexual desire
Constipation
Apathy
Appetite changes
sleep pattern changes
Depression s/s
Children and adolescents
Social withdraw
- Decreased interaction with peers; avoidance of play and recreational activities
Anxiety
Somatic symptoms
- headache & Stomachache
Irritable/ agitated rather than sad mood (especially adolescents)
Depression s/s
Older adults
Commonly associated with chronic illness;
- symptoms possibly confused with those of dementia or stroke
Depression is often missed in elderly due to ageism. Which leads to the elderly being under diagnosed and under treated. Thus you see a spike in suicides at age 75
Risk factors for depression
Female
LGBTQ community
Age: 40 years or younger
Postpartum period
Chronic medical illness
Absence of social support
Active alcohol or substance use disorder
Hx
- suicide attempts
- prior episodes of depression
- ACES
- Family Hx of suicide/ depression; first-degree relatives
Cognitive distortion
Filtering
Taking negative details and magnifying them while filtering out all positive aspects of a situation.
Only looking at the negative; not even allowing the positive thoughts to come in
- Ex. Get mad at your significant other for one small thing and forget all the positive things they’ve done
Cognitive distortion
Polaroid thinking (or black and white thinking)
Things are either “black or white.” We have to be perfect or we’re a failure—there is no middle ground or shades of gray.
- All or nothing thinking: “4.7 GPA isn’t good enough, I need a 5.0. No middle ground)
Cognitive distortion
Overgeneralization
Coming to a general conclusion based on a single incident or a single piece of evidence. If something bad happens only once, we expect it to happen over and over again.
- Ex. I failed the interview, this means I will never get a job.
Cognitive distortion
Jumping to conclusions
Without individuals saying so, we think we know what they are feeling and why they act the way they do.
- Ex. I know what you’re about to say
Cognitive distortion
Catastrophizing
We expect disaster to strike, no matter what. We exaggerate the importance of insignificant events.
- Ex. I’m going to die if I gain weight
Cognitive distortion
Personalization
A distorted belief that everything others do or say is somehow about us.
- Ex. A family moves and a child is having trouble making friends. The parents blame themselves
Cognitive distortion
Control fallacies
We see ourselves as helpless, a victim of fate, having no control, or we assume total responsibility for the pain and happiness of everyone around us (overcontrol).
- Ex. I’m sorry my stuttering makes you uncomfortable
Cognitive distortion
Fallacy of fairness
We feel resentful because we think we know what is fair, but other people won’t agree with us.
- Ex. Coworker gets promoted but we think the boss is being unfair because I should have been promoted
Cognitive distortion
Blaming
We hold other people responsible for our feelings and behaviors.
Nobody can “make” us feel any particular way—only we have control over our own emotions and emotional reactions.
Cognitive distortion
Shoulds
We have a list of ironclad rules about how we and others should and must behave.
- Ex. I should have arrived to the meeting earlier
Cognitive distortion
Emotional reasoning
We believe that what we feel must be true automatically. “I feel it; therefore it must be true.”
- Ex. I feel anxious so I know something dangerous will happen
Cognitive distortion
Global labeling
We generalize one or two qualities into a negative global judgment. For example, “I’m a loser” versus “In one situation, I failed.”
- Ex. Because she is always late to work she is irresponsible. I failed my test so i’m a failure
Cognitive distortion
Always being right
I have to prove my opinions and actions are correct. Being wrong is unthinkable.
Interventions for cognitive distortions
Health teaching and health promotion
Milieu therapy
Mindfulness-Based Cognitive Therapy
Group therapy
First-line psychotherapy interventions
- Cognitive Behavioral Therapy (CBT)
- Interpersonal psychotherapy (IPT)
- Problem-solving therapy (PST)- make lists?
- Cognitive Behavior Therapy for Insomnia (CBT-I)
interventions for depression:
Communication
- question underlying assumptions, and consider alternative explanations to problems
- identify cognitive distortions
- activities that raise self-esteem
- physical activities the patient enjoys
- supportive relationships/ support groups, therapy, and peer support
- referrals for spiritual/religious information
Interventions for depression:
Communication - Severely withdrawn
- mute: make observations
- Use simple, concrete words
- Allow time for the patient to respond
- Listen for covert messages and ask about suicide
Interventions for depression
Nutrition: anorexia
- small, high calorie/protein food and fluids frequently
- encourage family/ friend to remain with the patient during meals
- Offer patient preferred foods/ drinks choices. Involve the dietitian
- Weigh the patient weekly
Intervention for depression
Sleep: insomnia
- Encourage patient to get up and dress and to stay out of bed during the day
- periods of rest after activities
- Encourage the use of relaxation measures in the evening (warm bath, warm milk, progressive muscle relaxation techniques)
- Reduce environmental and physical stimulants in the evening-provide decaffeinated coffee, soft lights, quiet activities
Interventions for depression
Self-care deficit
- Encourage the use of toothbrush, wash cloth, soap, make up, shaving equipment, and so forth
- When appropriate, gift, step by step reminders, such as, “ wash the right side of your face, now the left”
Interventions for depression
Elimination: constipation
- Specifically monitor bowel movements
- Offer foods high in fiber, and provide periods of exercise
- Encourage the intake of fluids
- Evaluate the need for laxatives and enemas
Medication: First line treatment in depression
SSRIs
Offlable use of SSRIs
- panic disorder
- generalized anxiety disorder (GAD)
- OCD
- PTSD
- bulimia
- PMDD
- panic disorder
- social phobia
SSRIs MOA
- Increase serotonin
- inhibits serotonin transporter proteins (SERT)
therefore inhibiting reuptake of serotonin from the synaptic cleft
SSRI s/s
Common
Increased SI
Headaches
Dizziness
Sweating
Blurred vision
Dry mouth
Insomnia/drowsiness
Indigestion
Diarrhea/constipation
Loss of appetite/weight loss
Sexual dysfunction:
- Reduced libido/ Erectile dysfunction/ Difficulty achieving orgasm in men
Anxiety : first few weeks
SSRI s/s
Serious
Serotonin syndrome s/s
Agitation
Increased HR
Increased BP
Increased Temp
Sweating
Mydriasis: dilated pupils
Seizures
Hypertonia
Mild: restlessness, shivering, and diarrhea
Severe: “cog-wheel” rigidity: incremental movement/ not fluid movement, fever, and seizures.
Serotonin syndrome treatment
- muscle relaxants
- serotonin antagonists
SSRI interactions
- St. John’s wort
- OTC: dextromethorphan (cough and cold medications)
Caution when using SSRIs
Teratogenic: Pregnant/ Breastfeeding
Diabetic
Epileptic
Diagnosed with Kidney, Liver, or Heart Disease
Diagnosed with Bipolar I
Diagnosed with bleeding disorders
SSRI contraindications
Other SSRIs /antidepressants
NSAIDs/ Antiplatelet Medication
Clozapine and Pimozide
St. John’s Wort
Alcohol /Caffeinated drinks
Bipolar 1: can cause mania
Do not discontinue abruptly
Black box warning
SSRIs
higher risk of suicide
Teratogenic
SSRI drugs
F-SPEC
Fluoxetine (Prozac)
Sertraline (Zoloft)
Paroxetine (Paxil)
Escitalopram (Lexapro)
Citalopram: (Celexa)
Medication: Second line treatment for depression
SNRIs
SNDIs
How are SNDIs and SNRIs used in depression
may be added to SSRI (to augment)
counteract SSRI s/s: nausea, anxiety, or insomnia.
SNDI drugs
mirtazapine (Remeron)
SNRI/ SNDI MOA
- blocks presynaptic α2-noradrenergic receptors
- Increases norepinephrine
- Increases serotonin
SNRI DRUGS
- duloxetine (Cymbalta)
- venlafaxine (Effexor)
SNRI s/s
- Weight gain
- fatigue
- sexual dysfunction
- hypotension
- muscle cramps
- urinary retention
- constipation
duloxetine (Cymbalta) treats what
depression
chronic pain (neuropathy; improves sleep in pts with fibromyalgia)
duloxetine (Cymbalta) drug teaching
educate pt on why medication is given. Pt may refuse to take antidepressant meds for pain.
TCA drugs
CIAN
Clomipramine (anafranil)
Imipramine (Tofranil)
Amitriptyline (Elavil)
Nortriptyline (pamelor, Aventyl)
TCA treats what
- depression and chronic pain
- OCD/ anxiety
- Neuropathic pain
TCA MOA
- Blocks reuptake of norepinephrine and serotonin
- Increase NE/ SR
- Block: ACh, H1, A1
TCA s/s
dysrhythmias (cardiotoxic)
heart block (cardiotoxic)
Increased HR
Decreased BP; OTH (fall risk)
dizziness
weight gain
sedation/Drowsiness (give at night)
Sweating
anticholinergic effects:
- dry mouth
- blurred vision
- constipation- need immediate medical attention
- urinary retention- need immediate medical attention
MAOI drugs
phenelzine (Nardil)
tranylcypromine (Parnate)
MAOIS treat what
depression
panic disorder
social phobia/ anxiety
OCD
PTSD
bulimia
MAOI MOA
prevent monoamine oxidase from breaking down monoamines: norepinephrine, serotonin, and dopamine
Increases:
- norepinephrine
- serotonin
- Dopamine
MAOI S/S
Weight gain
Fatigue
Sexual dysfunction
Muscle cramps
Urinary retention
Constipation
HTN Crisis
Hypertensive crisis s/s
Increased BP
Increased HR
Increased Temp
Headache
AMS
Confusion
Nausea/ Vomiting
Chest pain
Arrhythmias
Palpitations
MAOI contraindications
Pseudoephedrine (Sudafed)
foods containing Tyramine
Other antidepressants
Foods containing tyramine
Chocolate
Wine
Cheese
Cured meats
Dried fruits
Avocado
Dry, pickled cured fish
Caffeine
Alcohol
ECT indications
- drug therapy failure
- acutely suicidal patient
- depressed patient with psychotic symptoms
- Severe manic behavior/ treatment resistant mania and pts with rapid cycling
ECT contraindications
Anticonvulsants
ECT caution
head trauma
seizure disorders
brain tumors
ECT teaching
- short term memory loss
- Don’t make any life changes/ decisions while undergoing ECT
- Sedation; anesthesia
- Do not drive; Fall risk
Most effective therapy for Depressed pts
Talk therapy
- CBT
What therapy revolves around reframing
CBT: reframes cognitive distortions
What therapy revolves around being mindful/ present in the moment
DBT: dialectical behavioral therapy
Which therapy involves action and is non-ruminative, goal, oriented, and positively reinforcing
Exercise
- At times as effective as talk therapy
Risk factors for bipolar
Genetics
Bipolar:
Which gender has a higher rate of depression and rapid cycling
Females
Bipolar:
Which gender has a higher rate of manic episodes
Males
High: dopamine, serotonin, norepinephrine= what?
Mania
Low: dopamine, serotonin, norepinephrine= what?
Depression
Bipolar comorbidity
Substance use
Anxiety disorders
- Panic disorder
- Social phobia
Unipolar
Only depression
Bipolar 1
Depression and mania
- Episodes last one week or need hospitalization
Most severe bipolar disorder?
Bipolar 1
Mania s/s
MOOD
Euphoric/elated/ energized (high)
irritable/hostile
labile: mood swings
Mania s/s:
Thoughts
- Grandiose delusions; hallucinations; disorganized
- Have many plans, but unable to organize thoughts to complete them;
- poor attention- easily distracted: hallmark symptom of mania
- Sexual thoughts; volger
Mania s/s
Communication
- Pressured; loud, rapid
- Circumstantial: adding unnecessary details
- Taginatial: when people think taginitially they lose the point they were trying to make and never find it again.
- LOA: mid sentence derailment
- flight of ideas; nonstop talking; disorganized
- clang associations: rhyming
- inappropriately demanding, sarcastic, crude
- Sexual inappropriate language
Mania s/s
Behavior
- agitation
- restless and disorganized;
- impulsive; may have angry outbursts;
- extreme goal oriented: too busy for eat, sleep (insomnia), sex;
- manipulative and pushes limits;
- wild & uncontrolled spending;
- dress extreme (colorful/bizarre); may disrobe; push limits
Interventions: acute Mania
Non-pharmaceutical
- reduce stimulation
- No group contact
- Physical exercise
- Set structure and limits on aggression
- finger foods/ water/ sleep/ self care
What is bipolar 2
Depression; Hypomania:
- 2 episodes
S/S hypomania
MOOD
- Good humor
- very sociable, boundless self-confidence
- Partake in get rich quick schemes
- inappropriately familiar with strangers (poor boundaries)
S/S Hypomania
Thoughts
Psychosis never present
S/S Hypomania
Communication
- Flight of Pressured speech but makes sense;
- sexual/crude themes; treats everyone as a friend
S/S Hypomania
- Overactive
- distractible
- increased sexual activity
- voracious appetite
- decreased sleep
- buying sprees & gives away money and gifts;
- flamboyant dress and excessive make-up
Cyclothymia
milder lows and milder highs
cycle over a period of 2 years
Rapid cycling
4-5 cycles (high & lows) within 1 year
Treating bipolar depression, with a common antidepressant alone, increases the risk for what
Bringing on a manic episode
Meds: bipolar depression
Quetiapine monotherapy
Olanzapine and fluoxetine combo
Acute bipolar depression: Lurasidone
Bipolar s/s children and adolescents
Depression: Intense rage
Reflective of developmental level of child
Hard to dx
Bipolar older adult
Greater neurologic abnormalities/ cognitive disturbances
- Incidence of mania decreased with age
Number one assessment for bipolar
DTO/DTS
Bipolar interventions
Communication :
- Use firm and calm approach: (“John come with me. Eat this sandwich” finger foods)
- Use short and concise explanations or statements
- Remain neutral; avoid power struggles and value judgments
- Set limits in a firm, non threatening, and neutral manner to prevent further escalation/ provide safe boundaries
- Be consistent in approach and expectations: limits manipulation
- Have frequent staff meetings
- Identify expectation in simple concrete terms with consequences
- Firmly redirect energy into more appropriate and constructive channels
- Use distraction techniques as a tool to de-escalate
Bipolar Key to treatment
Medication compliance
Bipolar: #1 one reason for relapse/hospitalization
Non-adherence to medication
Is nonadherence to medication egosyntonic or egodystonic
Egosyntonic
- They miss the highs of hypomania that make them to feel invincible, so they don’t believe they need the meds any longer
Drug of choice to treat bipolar
Lithium
When is lithium used as an augmentation?
Major depression
- Prevent manic episodes/anti-suicidal properties
Lithium MOA
its a salt; works on sodium channels.
Decreases dopamine & glutamate
Increases GABA
When should you D/C lithium
- excessive diarrhea
- vomiting
- sweating
- Drug serum: 1.5+ mEq/ L
Lithium onset
5-7 days
Lithium labs
Cr
BUN
GFR
TSH
Drug serum
Lithium contraindications
NSAIDS
- increase effects of lithium
Lithium therapeutic range
0.6 - 1.2
Normal Lithium s/s
Drug serum range?
< 1.5 mEq/L
fine hand tremor
polyuria
mild thirst
mild nausea (give with food)
mild weight gain
Mild Lithium intoxication s/s
Drug serum range
1.5 - 2.5 mEq/L
nausea
vomiting
lethargy
coarse hand tremor
fatigue
Moderate Lithium intoxication s/s
Drug serum range?
2.5 - 3.5 mEq/L
confusion
agitation
delirium
tachycardia
hypertonia
Severe Lithium intoxication s/s
Drug serum range?
> 3.5 mEq/L
Coma
seizures
hyperthermia
hypotension
Lithium Antidote
No antidote
- flush drug from system
Lithium levels:
Dehydration
High lithium levels
Lithium levels
Over hydrated
Low lithium levels
High Na intake
Lithium levels
Low lithium levels
Low Na intake
Lithium levels
High Lithium Levels