tabletting Flashcards
what is magnesium stearates purpose in medications?
to be a lubricant and to delay breakdown and absorption
what is polyplasdone an examples of?
rheology modifier and super disintegrant
properties of polyplasdone?
‘water insoluble
non-ionic
swellable
crosslinked PVP polymer’
how does polyplasdone rapidly disintegrate ?
has porous particle morphology
what are the pros of using avicel?
what are pharmaceutical intermediate?
chemical compounds that form the API and need to be purified
what is starch’s use in pharmaceuticals?
binder, diluent and disintegrant.
what is the purpose of an disintegrant?
to breakdown tablet so it can be absorbed
what does Pharma Grade Starch Powder contain?
amylopectin and amylose
what is spray dried lactose used for?
‘filler-binders for direct compression’
pros of spray filled lactose?
very good flowability
very stable
low hygroscopicity
fast disintegration
good to use with bad flowing API
how is milled lactose produced?
‘milled at different degrees of fineness’
what are the properties of milled lactose?
cohesive and have poor flowability
pros of milled lactose?
‘batch consistency
dry granulation
can get them as blend, sachets, Trituration’s and premixes’
