Manufacturing medicinal products- the science of medicinal products year 1 practical 1

Question 1

example of topical medicine?

Answer 1

cream and ointments

Question 2

what is topical?

Answer 2

keeps API within the skin

Question 3

what are transdermal medicine?

Answer 3

API delivered to systemic circulation via skin

Question 4

what are the roles of excipients?

Answer 4

help prepare form of dosage
helps patients body accept the drug
help with function of dosage form

Question 5

why is the base important?

Answer 5

determines the release characteristic of the drug

Question 6

what are ointments, creams and pastes know as?

Answer 6

semi-solid base

Question 7

what is a benefit of excipients?

Answer 7

believed to not affect the action of the drug

Question 8

what are specials?

Answer 8

for patients who can’t find marketed product

Question 9

properties of ointments?

Answer 9

protective properties
form hydrophobic layers to reduce water loss from skin
greasy
doesn’t contain water so microorganisms don’t grow easily

Question 10

why are creams packed in a tube but ointments aren’t?

Answer 10

creams contain water so risk of microorganisms growing

Question 11

why are creams less greasy

Answer 11

o/w emulsion
has an outer continuous phase and inner dispersed phase

Question 12

what is used for stability of creams?

Answer 12

two emulsifying agents

Question 13

how to destabilise creams?

Answer 13

cracking- separation of emulsion
freezing- leaves cream unstable

Question 14

BP freshly prepared?

Answer 14

no more than 24 hours before use of drug

Question 15

recently prepared?

Answer 15

worsening if stored for more than 4 weeks at 15-25 degrees celcius

Question 16

when do creams go out of date?

Answer 16

two weeks after maufactured

Question 17

when do ointments go out of date?

Answer 17

4 weeks after manufactured