Tablets Flashcards
Tablets are the most popular dosage forms. TRUE or FALSE
TRUE
Oral route is convenient and a safe way of drug administration. TRUE or FALSE
TRUE
Tablets have better physical and chemical stability than liquid dosage forms. TRUE or FALSE
TRUE
Tablets provide accurate dosing of a drug (fixed dose per tablet). TRUE or FALSE
TRUE
Tablets ate convenient to handle and use (patient preference). TRUE or FALSE
TRUE
Production procedures of tablets are quality controlled. TRUE or FALSE
TRUE
Tablets can be produced on a large scale with low cost. (manufacturer’s consideration). TRUE or FALSE
TRUE
State 5 advantages of tablets as a dosage form
- Oral route is convenient
- Better physical and chemical stability than liquid dosage forms
- Accurate dosing of the drug (fixed dose per tablet)
- Convenient to handle
- Mass production, low costs
Tablets usually contain excipients in addition to
the active ingredients. TRUE or FALSE
TRUE
In order for drug to be absorbed, it must first be dissolved. TRUE or FALSE
TRUE
Tablets can be administered by ?
- Swallowing whole
- Swallowing upon chewing
- Retaining in mouth (therefore avoids acidic environment of stomach);
- Buccal (in the cheek)- designed to release drug slowly
- Sublingual (under the tongue) - designed for fast action
- Dissolve in water before administration
State 3 disadvantages of tablets as a dosage form
1) Poor bioavailabilty of poorly water-soluble or poorly absorbable drugs
2) Difficult to swallow for some patients
3) Some drugs may irritate G.I tract
STATEMENT: When designing tablet formulations, you need to consider what features you want the tablet to have hence what excipients to use
Learn!
State some general attributes of a good tablet
- Should have sufficient mechanical strength to survive transport and handling
- Weight and size should be consistent
- Drug should be released in controlled, reproducible way
- Biocompatible; non-toxic excipients, contaminants and microorganisms
- Physically, Chemically and biologically stable4
How many stages are in tablet formation, state and describe them.
3 stages
1) FILLING STAGE -Powder fills the die by gravity or centrifugal force
2) COMPRESSION STAGE -Upper punch lowers into the die and powder is compressed; then upper punch moves up
3) EJECTION STAGE -Lower punch moves up to reject the tablet
Define ‘Powder Compression’
Reduction of powder volume due to application of force
Define ‘Powder Compaction’
The formation of a porous specimen of defined geometry upon powder compression
STATEMENT Tablets are formed by forcing particles into close proximity to each other by powder compaction. Therefore, particles cohere into a POROUS solid of defined shape
LEARN!
State 2 instruments used in tablet formation
1) Single punch tablet press
2) Rotary tablet presses
A single punch tablet press consists of; One die and One pair of punches (upper and lower). TRUE or FALSE
TRUE
In a single punch tablet press, the ‘hopper shoe’ moves to and from the die by ?
Translational or Rotational movement
The tablet weight (amount of material filled into the die) is controlled by the position of the upper or lower punch ?
Position of Lower punch
In a single punch tablet press, does the upper or lower punch remain stationary during compaction ?
Lower
About how many tablets can be formed per min using a single punch tablet press
About 200 tablets
State one difference between a Single punch tablet press and a Rotary tablet press
Single punch tablet press consists of ONE die and ONE set of punches
WHILST, Rotary tablet presses consist of MY DIE (on the die table) and MANY PAIRS OF PUNCHES
In a Rotary tablet press, the die tablet and punches rotate together, therefore the same punches always work with the same die. TRUE or FALSE
TRUE
Which tablet press is more suitable for mass production of tablets and why ?
Rotary tablet press as about 10,000 tablets is formed per min compared with 200 tablets per min achieved in single punch tablet press.
