Oral solid dosage forms - CAPSULES

Question 1

State some common oral doasge forms

Answer 1

• Tablets
• Capsules
• Powders/Granules
• Pastilles, Lonzenges
• Gums
• Oral lyophilisates (i.e Maxalt melt (rizatriptan benzoate))

Question 2

Capsules - Capsula; Small box

Answer 2

LEARN

Question 3

Capsules are available as Hard or Soft gelation capsules

Answer 3

LEARN

Question 4

Describe the manufacture of Capsules

Answer 4

Avoids certain processes (i.e. compaction, possibly granulation)

Difficult to counterfeit

Specialist filling equipment is normally required

Question 5

Capsules may be used to increase oral bioavailability of which type of drugs ?

Answer 5

Poorly water-soluble drugs (especially when liquid-filled capsules are used)

Question 6

Capsules are an easy method by which to deliver liquids. TRUE or FALSE

Answer 6

TRUE

Question 7

Bioavailabilty of capsules can depend on homogenity of fill

Answer 7

LEARN

Question 8

Why might physical and chemical stability, particularly for liquid-filled capsules be an issue ?

Answer 8

Due to stability of API in liquid media and physical stability of external capsule casing with incorporated liquid

Question 9

What is Gelatin derived from ?

Answer 9

Animal tissue