Tablets Flashcards
These are solid pharmaceutical dosage forms containing drug substances with or without suitable diluents and are prepared either by compression or molding.
Tablets
Two (2) Types of Tablets
- Molded Tablets / Tablet Triturates
- Compressed Tablets
These are usually made from moist material using triturate mold that gives them the shape of cut sections of cylinder. Prepared from mixtures of medicinal substances and diluents usually consisting of lactose and powdered sucrose in varying proportions. The powders are dampened with solutions containing high percentage of alcohol. These are pressed into molds, removed, and allowed to dry.
Molded Tablets / Tablet Triturates
Two (2) Types of Molded Tablets
- Dispensing Tablets
- Hypodermic Tablets
These tablets provide the convenient quantity of potent drug that can be incorporated readily into powders and liquids. These tablets are supplied primarily as convenience for extemporaneous compounding and should never be dispensed as dosage form. A tablet prepared by molding or by compression; used by the dispensing pharmacist to obtain certain potent substances in convenient form for accurate compounding. Formerly used to prepare bulk solutions of germicidal chemicals, bichloride of mercury. Not intended for internal use.
Dispensing Tablets
These are soft, readily soluble tablets and were originally used for the preparation of solutions to be injected.
Hypodermic Tablets
These tablets are formed by the process of pressing powdered, crystalline or granular materials, alone or in combination with excipients to form compact adherent mass of predetermined shape.
Compressed Tablets
These are tablets recommended to “speed up” disintegration by breaking up or mastication in the mouth.
Chewable Tablets
Its physical features are similar to buccal tablets, but they are placed underneath the tongue. Usually small, flat tablet intended to be inserted beneath the tongue, where the active ingredient is absorbed directly through the oral mucosa; such as tablet (nitroglycerin) dissolves very promptly.
Sublingual Tablets
A small, flat, oval tablets intended for buccal administration by inserting into the buccal pouch to dissolve or erode slowly.
Buccal Tablets
These are small tablets compressed without excipients.
Implantation Tablets or Pellets
These are specially formulated and shaped tablets, which are inserted into the vaginal canal using special inserting device or fingers. It exerts localized effects.
Vaginal Tablets, Tablet Suppositories or Inserts
Five (5) Types of Special Oral Tablets
- Multiple Layered Tablets
- Layered Tablets
- Press-Coated Tablets
- Sugar-Coated Tablets
- Film-Coated Tablets
These are tablets prepared by the compression of several different granulations fed into the die in succession, one on top of the other in layers.
Multiple Layered Tablets
These are prepared by compressing additional granulation on previously compressed granulation.
Layered Tablets
These are prepared by feeding previously compressed tablets into special tableting machine, and compressing another granulation layer “around” the preformed tablet.
Press-Coated Tablets
These are compressed tablets containing sugar coating. Such coatings may be colored and are beneficial in covering up drug substances possessing objectionable tastes or odors, and in protecting materials sensitive to oxidation.
Sugar-Coated Tablets
These are covered with the thin layer film of water-soluble material. A number of polymeric substances with film-forming properties may be used.
Film-Coated Tablets
These are tablets, which are employed to produce Carbon Dioxide, by chemical reaction of the components upon the addition of water.
Effervescent Tablets
Two (2) General Methods of Effervescent Tablets
- Wet Fusion Method
- Dry Fusion Method
The granules are tabletted, while still damp, since citric acid acts as the lubricant. The tablets are oven dried at 70 to 75 degrees Celsius.
Wet Fusion Method
The components are blended with the inclusion of 15% to 25% citric acid monohydrate. The batch is heated while mixing, until the molecule of water of citric acid is release, which becomes the binding agent of the granules.
Dry Fusion Method
These are used for preparing solutions or imparting given characteristics to solutions must be labeled to indicate that they are not be swallowed.
Tablets for Solution
These tablets are designed so that the administration of single dose unit provides the immediate release of amount of drug, that promptly produces the desired therapeutic effect; and gradual, continued release of the other amounts of the drug, to maintain this level of effect over an extended period of time, usually 8 to 12 hours. The advantage of this type of tablet is the production of equilibrium blood levels of the drug without the need for repeated administration of the dosage units.
Sustained Release Tablets
