Tablet Defects Lecture

Question 1

QC for tablets

Answer 1

Weigh variation 
Content Uniformity
Tablet thickness
Friability
Hardness
Disintegration
Dissolution

Question 2

Tests for weight variation

Answer 2

Within 5%

Sample through out

Question 3

Content Uniformity test

Answer 3

85-115%

Pulverized and dissolved to analyze the drug content

Question 4

Tablet thickness test

Answer 4

Thickness or diameter is measured by micrometer calipers, thickness gauge, Ames Dial Comparator
5%

Question 5

Tablet hardness test

Answer 5

Hard enough to resist breaking down during normal handleing but soft enough to disintegrate in a timely fashing

Question 6

Lozenges, buccal, chewable tablets

Answer 6

Hard to dissolve slowly

Question 7

Hypodermic, compressed tablet triturates, rapidly disintegrating tablets

Answer 7

Soft

Question 8

Friability test

Answer 8

Resistance to abrasion or tendency of a tablet to crumble

Loss in weight = friability

Question 9

Disintegration Test

Answer 9

Time required by tablets to break up into particles that are small enough to pass through #10 mesh screen
Must disintegrate within 30 minutes

Question 10

Dissolution Test

Answer 10

Measure the proportion of drug dissolved in a stated time under standardized condition in vitro