TABLET CRUSHING

Question 1

Risks to Healthcare Workers and Carers

Answer 1

Carcinogenic : methotrexate
Teratogenic : Valganciclovir
Hormones : corticosteroids , contraceptive Irritation : alendronate , Diflunisal , isotretinoin

Question 2

Drug instability

Answer 2

1- (protect from gastric acid ) : in vivo drug degradation will increase, with less drug available to produce the desired clinical effect.
2- Coating (protect drugs that highly sensitive to the light ) example : Nifedipine

Question 3

Changes in drug Pharmacokinetics and Bioavailability

Answer 3

This is particularly important change for
drugs:
e.g. phenytoin, digoxin, carbamazepine, theophylline, or sodium valproate

Question 4

Drug Irritation

Answer 4

edications may
e.g. nitrofurantoin, potassium chloride, alendronate, diclofenac

Question 5

Bitter Tasting Drugs

Answer 5

Sugar coating drugs : Ibuprofen , Quinine
- Film coated .
Examples of bitter or unpleasant tasting drugs: cefuroxime axetil, ciprofloxacin

Question 6

Anesthetic effect on tongue
NGT tube blockage

Answer 6

Anesthetic effect on tongue : Sertraline
- NGT tube blockage : e.g. omeprazole & lansoprazole
enteric coated granules.