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PATHOmorphology Final Prep 2016/2017 > TABLES for - PP - Neoplasms introduction 2016 > Flashcards

TABLES for - PP - Neoplasms introduction 2016 Flashcards

1
Q

Epithelial:

Immunohistochemistry

A
  • Cytokeratins
  • EMA
  • PSA
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2
Q

Lymphoid:

Immunohistochemistry

A

LCA

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3
Q

Melanocytic:

Immunohistochemistry

A

HMB45, MelanA, S100

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4
Q

Muscle:

Immunohistochemistry

A
  • Desmin

- Actin

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5
Q

Glial:

Immunohistochemistry

A
  • GFAP

- S100

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6
Q

Neuroendocrine:

Immunohistochemistry

A
  • Chromogranin A
  • Synaptophysin
  • Insulin
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7
Q

Vascular:

Immunohistochemistry

A
  • CD34
  • CD31
  • FVIII
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8
Q

Histiocytic:

Immunohistochemistry

A

CD68

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9
Q

Embryonal antigens:

Immunohistochemistry

A
  • AFP

- CEA

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10
Q

RB:

Inherited cancer syndromes

A

retinoblastoma retinoblastoma

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11
Q

P53:

Inherited cancer syndromes

A

Li Fraumeni syndrome (various tumours)

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12
Q

p161NK4A:

Inherited cancer syndromes

A

melanoma

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13
Q

APC:

Inherited cancer syndromes

A

familial adenomatous polyposis/colon cancer

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14
Q

NF1, NF2:

Inherited cancer syndromes

A

neurofibromatosis 1 and 2

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15
Q

BRCA1, BRCA2:

Inherited cancer syndromes

A

breast and ovarian breast and ovarian tumour

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16
Q

MEN1, RET:

Inherited cancer syndromes

A

multiple endocrine neoplasia 1 and 2

17
Q

MSH2, MLH1, MSH6:

Inherited cancer syndromes

A

hereditary nonpolyposis colon cancer

18
Q

Familial cancers:

A

familial clustering of cases but role of inherited predisposition not clear

* Breast cancer (not linked with BRCA1 or BRCA2) 
* Ovarian cancer 
* Pancreatic cancer
19
Q

Inherited autosomal recessive syndromes of defective DNA repair:

A
  • Xeroderma pigmentosum
  • Ataxia teleangiectatica
  • Fanconi anemia

PATHOmorphology Final Prep 2016/2017 (3 decks)

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