Tables Flashcards
What is the recommended thromboprophylaxis for a patient with a high risk of symptomatic VTE (~6.0%) and an average risk of bleeding (~1%)?
A. IPC
B. LDUH or LMWH
C. LDUH or LMWH plus IPC
D. Fondaparinux or low-dose aspirin
C. LDUH or LMWH plus IPC. For patients with a high risk of symptomatic VTE and an average risk of bleeding, the table recommends a combination of pharmacological (LDUH or LMWH) and mechanical (IPC) prophylaxis.
What is the suggested thromboprophylaxis for a patient undergoing high-risk cancer surgery with a high risk of bleeding?
A. IPC until risk for bleeding diminishes and pharmacologic prophylaxis can be added
B. LDUH or LMWH plus IPC
C. Fondaparinux or low-dose aspirin
D. No specific prophylaxis
A. IPC until risk for bleeding diminishes and pharmacologic prophylaxis can be added. This recommendation minimizes the risk of bleeding while still addressing the need for thromboprophylaxis.
How would you manage a patient who has a moderate risk of symptomatic VTE (~3.0%) and a high risk of bleeding (~2%)? Why?
For a patient with a moderate risk of symptomatic VTE and a high risk of bleeding, IPC would be recommended. This mechanical method of prophylaxis helps prevent the formation of blood clots without introducing the bleeding risks associated with pharmacological methods like LDUH or LMWH.
How would you manage a high-risk patient for whom LDUH and LMWH are contraindicated or not available, and who has an average risk of bleeding?
For such a patient, fondaparinux or low-dose aspirin (160 mg), IPC, or both are recommended. These options provide alternatives for pharmacologic prophylaxis when LDUH and LMWH are contraindicated or unavailable.
What is the recommended thromboprophylaxis for a patient with very low risk for symptomatic VTE (<0.5%)?
No specific prophylaxis.
What does IPC stand for in the context of thromboprophylaxis?
Intermittent Pneumatic Compression.
What are LDUH and LMWH in the context of thromboprophylaxis?
Low-Dose Unfractionated Heparin (LDUH) and Low Molecular Weight Heparin (LMWH).
What is recommended for patients undergoing high-risk cancer surgery with an average risk of bleeding?
LDUH or LMWH plus IPC and extended-duration prophylaxis with LMWH post-discharge.
What is recommended for a high-risk patient for whom LDUH and LMWH are contraindicated or not available, and who has an average risk of bleeding?
Fondaparinux or low-dose aspirin (160 mg), IPC, or both.
What is fondaparinux?
Fondaparinux is an anticoagulant medication that helps prevent blood clots. It is a synthetic pentasaccharide (a sugar molecule composed of five sugar units) that binds to and inhibits the action of a natural anticoagulant inhibitor in the body called antithrombin III. This binding leads to the inhibition of Factor Xa, a key player in the coagulation cascade, and thereby prevents the formation of blood clots.
Fondaparinux is commonly used for the prophylaxis of deep vein thrombosis (DVT) in patients undergoing hip fracture surgery, hip replacement surgery, knee replacement surgery, or abdominal surgery. It is also used to treat acute DVT and pulmonary embolism in conjunction with warfarin, another anticoagulant medication.
As with other anticoagulants, the primary side effect of fondaparinux is an increased risk of bleeding. Therefore, it is used with caution in patients who have a high risk of bleeding. Its use may also be contraindicated in individuals with kidney disease due to decreased drug clearance. It does not require monitoring like warfarin but has a longer half-life which can be problematic in situations where reversal of anticoagulation is needed.
What is the recommended management for a Grade 1–2 distal ureteral injury?
A. Ureteroneocystotomy ± psoas hitch or Boari flap
B. Ureteral stent or nephrostomy tube × 2–6 weeks
C. Uretero-ureterostomy over ureteral stent
D. Percutaneous nephrostomy tube
B. Ureteral stent or nephrostomy tube for 2–6 weeks (stent preferred)
What is the preferred method for delayed repair of a Grade 5 proximal ureteral injury?
A. There is no preferred method, and options include Ureterocalicostomy, Transureteroureterostomy, Ileal ureter interposition, Autotransplantation, or Appendiceal on lay or buccal mucosal graft.
B. Ureterocalicostomy
C. Transureteroureterostomy
D. Ileal ureter interposition
A. There is no preferred method, and options include Ureterocalicostomy, Transureteroureterostomy, Ileal ureter interposition, Autotransplantation, or Appendiceal on lay or buccal mucosal graft.
How would you manage a Grade 3–5 injury in the mid or proximal ureter?
For a Grade 3–5 mid or proximal ureteral injury, a uretero-ureterostomy over a ureteral stent would be the management of choice.
What are the options for delayed repair of a Grade 5 proximal ureteral injury?
For a Grade 5 proximal ureteral injury, options for delayed repair include Ureterocalicostomy, Transureteroureterostomy, Ileal ureter interposition, Autotransplantation, or Appendiceal on lay or buccal mucosal graft.
What is the treatment for a Grade 1-2 distal ureteral injury?
Ureteral stent or nephrostomy tube for 2–6 weeks (stent preferred).
What is the management approach for a Grade 3–5 distal ureteral injury?
Ureteroneocystotomy with or without psoas hitch or Boari flap.
How do you manage a Grade 3–5 mid or proximal ureteral injury?
Uretero-ureterostomy over a ureteral stent.
What are the options for delayed repair of a Grade 5 proximal ureteral injury?
Options include Ureterocalicostomy, Transureteroureterostomy, Ileal ureter interposition, Autotransplantation, or Appendiceal on lay or buccal mucosal graft.
What characterizes a Grade 1 ureteral injury?
A. Contusion or hematoma without devascularization
B. Less than 50% transection
C. More than 50% transection
D. Complete transection with devascularization greater than 2 cm
A. Contusion or hematoma without devascularization
What grade of ureteral injury represents complete transection with ≤2 cm devascularization?
A. Grade 3
B. Grade 4
C. Grade 5
D. Grade 6
B. Grade 4
What is the difference between a Grade 2 and Grade 3 ureteral injury?
A Grade 2 ureteral injury involves a laceration resulting in less than 50% transection of the ureter, whereas a Grade 3 ureteral injury involves a laceration resulting in more than 50% transection.
What does a Grade 6 ureteral injury indicate?
A Grade 6 ureteral injury indicates that the ureter is not salvageable, which means that surgical or medical intervention is unlikely to restore its function.
What is a Grade 1 ureteral injury?
A Grade 1 ureteral injury is characterized by a contusion or hematoma without devascularization.
What is a Grade 4 ureteral injury?
A Grade 4 ureteral injury is a complete transection with devascularization less than or equal to 2 cm.