Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Memorise > T2DM Drugs > Flashcards

T2DM Drugs Flashcards

1
Q

Metformin - side effects

A

GI upset

Lactic acidosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Metformin - contraindictations

A

eGFR <30

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Metformin - mechanism of action

A

Increases insulin sensitivity and decreases hepatic gluconeogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Sulfonylureas - example

A

Gliclazide

Glimepiride

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Sulfonylureas - mechanism of action

A

Stimulate beta cells to produce insulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Sulfonylureas - side effects

A

Hypoglycaemia
Weight gain
Hyponatraemia/SIADH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Thiozolidinediones - example

A

Pioglitazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Pioglitazone - mechanism of action

A

Activate PPAT-gamma which increases adipogenesis and the uptake of fatty acids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Pioglitazone - side effects

A

Weight gain
Fluid retention
Deranged LFTs
Fracture

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

DPP-4 Inhibitor - examples

A

-gliptins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

DPP-4 inhibitors - mechanism of action

A

Increases incretin which inhibits glucagon secretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

DPP-4 inhibitors - side effects

A

Risk of pancreatitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SGLT-2 Inhibitors - examples

A

-gliflozins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

SGLT-2 inhibitors - mechanism of action

A

Inhibits reabsorption of glucose in the kidneys

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

SGLT-2 inhibitors - side effects

A

UTI, weight loss

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

GLP-1 Agonists - example

A

-tides

17
Q

GLP-1 agonist - mechanism of action

A

Incretin mimetic - inhibits glucagon secretion

18
Q

GLP-1 agonist - side effects

A

N+V
Pancreatitis
Weight loss

19
Q

Which T2DM drug is given subcut?

A

GLP-1 agonists (-tides)

20
Q

Which of the T2DM drugs are hypoglycaemic agents?

A

Sulfonylureas

21
Q

Which cause weight gain?

A

Sulfonylureas

Pioglitazone

22
Q

Which drugs can be used as normal during surgery?

A

DPP-4 inhibitors and GLP-1 agonists

23
Q

How should metformin be altered for surgery?

A

If OD or BD - take as normal

If TDS - omit lunchtime dose

24
Q

How should sulfonylureas be altered for surgery?

A

If OD - omit

If BD - omit morning dose (if afternoon operation, omit both doses)

25
Q

How should SGLT-2 inhibitors be altered for surgery?

A

Omit dose on day

26
Q

How should patients on insulin be managed during surgery?

A

If good glycaemia control and short op - usual regime

If long op, or very bad glycaemia control (HbA1c >69) - variable rate insulin infusion.

27
Q

How should insulin doses be altered for surgery?

A

OD insulin - 20% lower dose day before and day of

BD insulin - half the morning dose on the day of only

Memorise (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions