T2 DM

Question 1

Metformin - action

Answer 1

Increases peripheral insulin sensitivity

Increases hepatic glucose uptake

Question 2

Metformin - side effects (2)

Answer 2

Lactic acidosis

GI disturbance

Question 3

Metformin - CI

Answer 3

AKI

Recent MI

Question 4

DPP4 inhibitors - action

Answer 4

Inhibit GLP1 breakdown

Question 5

DPP4 inhibitors - side effects (3)

Answer 5

Hypoglycaemia
GI upset
Pancreatitis

Question 6

GLP1 analogues - action

Answer 6

Increases insulin secretion and sensitivity

Question 7

GLP1 analogues - side effects (2)

Answer 7

Hypoglycaemia

GI upset

Question 8

Intestinal alpha glucosidase inhibitors - action

Answer 8

Delay intestinal carbohydrate absorption

Question 9

SGLT2 inhibitors - action

Answer 9

Increase urinary glucose loss

Question 10

SGLT2 inhibitors - side effects (2)

Answer 10

Increased risk of UTIs

Necrotising fasciitis of genitalia or perineum

Question 11

SU - action

Answer 11

Depolarise islet cells in pancreas –> increases insulin release

Question 12

SU - side effects (4)

Answer 12

Hypoglycaemia
Increases weight
SIADH
Cholestatic liver dysfunction

Question 13

Thiazolidinedione - action

Answer 13

Increase peripheral insulin sensitivity

Question 14

Thiazolidinedione - side effects (6)

Answer 14

Fluid retention
Increases weight
Worsens heart failure
Liver dysfunction
Fractures
Bladder cancer

Question 15

Thiazolidinedione - CI

Answer 15

Heart failure