Side effects Flashcards

1
Q

Omeprazole (5)

A
Hypomagnesaemia 
Increased risk c.diff infection
Microscopic colitis
Hyponatraemia 
Osteoporosis
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2
Q

Adenosine (8)

A
Chest pain
Flushing 
Abdo discomfort
Headache
Hypotension 
Dry mouth
Dyspnoea 
Arrhythmias
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3
Q

Amiodarone (11)

A
Hypothyroidism
Hyperthyroidism
Corneal deposits
Pulmonary fibrosis
Liver fibrosis 
Photosensitivity 
Slate grey appearance
Bradycardia
Lengthens QT
Optic neuritis
Increased risk idiopathic intracranial hypertension
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4
Q

Digoxin (4)

A

Yellow green vision
Gynaecomastica
Anorexia
Confusion

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5
Q

Digoxin toxicity (10)

A
Nausea
Vomiting
Diarrhoea
Abdo pain 
Headache
Dizziness
Confusion
Delirium
Vision - blurred, yellow
Cardiac - irregular, VT, VF, sinoatrial block, atrioventricular block
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6
Q

Ciprofloxacin (5)

A
Increases INR
Tendinitis 
Tendon rupture
Lowers seizure threshold
Lengthens QT interval
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7
Q

Nitrofurantoin (2)

A

Hepatitis

Hepatic failure

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8
Q

Trimethoprim (4)

A

Isolated increase in creatinine
Rashes
Pruritic
Suppression of haematopoiesis

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9
Q

Amitriptyline (10)

A
Hyponatraemia
Abnormal LFTs
Leukopenia
Thrombocytopenia
Drowsiness
Dry mouth
Blurred vision 
Constipation 
Urinary retention 
Overflow incontinence
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10
Q

Sertraline (7)

A
Hyponatraemia
GI bleed
QT interval prolongation
Mania
Serotonin syndrome
Duodenal ulcer
Erectile dysfunction
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11
Q

Amlodipine (5)

A
Peripheral oedema
Nausea
Dizziness/postural symptoms
Palpitations
Flushing
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12
Q

Ramipril (6)

A
Dizziness/postural symptoms
Nausea/vomiting
Diarrhoea
Chest pain
Weakness
Angioedema
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13
Q

Verapamil (4)

A

Constipation
Hypotension
Bradycardia
Flushing

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14
Q

Carbamazepine (8)

A
Decreased INR
Dizziness + ataxia 
Drowsiness
Headache
Visual disturbance 
Steven Johnson syndrome
Leukopenia + agranulocytosis
Hyponatraemia secondary to SIADH
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15
Q

Phenytoin (9)

A
Cerebellar syndrome 
Gingival hyperplasia 
Decreased INR
Peripheral neuropathy 
Megaloblastic anaemia
Osteomalacia 
Lymphadenopathy 
Dyskinesia
Dupuytren's contracture
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16
Q

Sodium valproate (9)

A
Increases INR
Weight gain
Nausea
Alopecia
Ataxia
Tremor
Hepatotoxicity 
Pancreatitis
Thrombocytopenia
Hyponatraemia
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17
Q

Chlorpromazine (typical) (15)

A
Parkinsonism
Acute dystonia
Akathisia
Tardive dyskinesia
Increased risk stroke/VTE
Dry mouth
Blurred vision 
Urinary retention 
Constipation 
Sedation 
Weight gain 
Increased prolactin 
Impaired glucose tolerance 
Neuroleptic malignant syndrome
Prolonged QT
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18
Q

Clozapine (atypical) (9)

A
Agranulocytosis
Hyperglycaemia
QT interval prolongation
Sepsis
Idiopathic hyperthermia 
Weight gain 
Hypersalivation
Increased prolactin 
Extrapyramidal side effects
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19
Q

Finasteride (4)

A

Erectile dysfunction
↓ libido
Ejaculation problems
Gynaecomastica

20
Q

Tamulosin (4)

A

Dizziness
Postural hypotension
Dry mouth
Depression

21
Q

Beta blockers (10)

A
Bronchospasm - avoid w/ asthma
Erectile dysfunction
Constipation
Dizziness/postural symptoms
Dry mouth
Cold hands + feet
Vivid nightmares
Tiredness 
Exacerbates plaque psoriasis 
Insomnia 
↓ hypoglycaemic awareness
22
Q

Metformin (4)

A

Lactic acidosis
GI disturbance
Diarrhoea
Bloating

23
Q

DPP4-inhibitors (gliptins) (3)

A

Hypoglycaemia
GI upset
Pancreatitis

24
Q

GLP-1 analogues (atide) (2)

A

Hypoglycaemia

GI upset

25
Q

Acarbose (2)

A

Flatulence

GI disturbance

26
Q

SGLT2 (2)

A

Increased risk UTIs

Necrotising faciitis of genitalia and perineum

27
Q

SU (azide) (4)

A

Hypoglycaemia
↑ weight
SIADH
Cholestatic liver dysfunction

28
Q

Thiazolidinediones (6)

A
Fluid retention
↑ weight
Worsening heart failure
Liver dysfunction
Fractures 
Bladder cancer
29
Q

Bendroflumethiazide (7)

A
GI upset
Headache
Dizziness/postural symptoms
Numbness/tingling
Blurred vision
Hypokalaemia 
Hyponatraemia
30
Q

Furosemide (7)

A
Sensorineural hearing loss
Hypocalcaemia → osteoporosis 
Hypotension
Hyponatraemia 
Renal impairment
Gout 
Hyaline casts in urine
31
Q

Ciclosporin (8)

A
Gum hypertrophy 
Hypertrichosis
Hypertension
Hyperkalaemia
Hyperglycaemia 
Hepatotoxicity 
↑ risk idiopathic intracranial hypertension
SCC or BCC
32
Q

Metoclopramide (4)

A

Can induce oculogyric crisis - dystonic reaction in young women
Galactorrhoea
Raised prolactin
Extrapyramidal effects

33
Q

Rotigotine (parkinsons) (5)

A
Impulse control disorder
Pathological gambling
Hypersexuality 
Binge eating
Compulsive shopping
34
Q

Ethambutol (4)

A

Blurry vision
↓ visual acuity
Colour blindness
Optic neuritis

35
Q

Isoniazid (4)

A

Drug induced lupus
Peripheral neuropathy
Hepatitis
Agranulocytosis

36
Q

Pyrazinamide (4)

A

Hyperuricemia → gout
Arthralgia
Myalgia
Hepatitis

37
Q

Rifampicin (2)

A

Hepatitis

Orange bodily secretions

38
Q

Allopurinol

A

Bone marrow suppression

39
Q

Azathioprine (4)

A

Bone marrow depression
Nausea/vomiting
Pancreatitis
↑ risk non melanoma skin cancer

40
Q

Methotrexate (8)

A
Bone marrow suppression
Anaemia 
Leucopenia
Agranulocytosis
Thrombocytopenia
Fibrosis in liver + lung
Mucositis 
Pneumonitis
41
Q

Prednisolone (11)

A
Insomnia 
Cushings syndrome
Hirsutism 
Osteoporosis 
Avascular necrosis of femoral head
Mania
Depression
Psychosis 
Peptic ulceration
Acute pancreatitis 
Proximal myopathy
42
Q

Sildenafil (4)

A

Headaches
Facial flushing
Dyspepsia
Blue green tingeing of vision

43
Q

Statin (2)

A

Myopathy - myalgia, myositis, rhabdomyolysis, ↑ CK

Liver impairment

44
Q

Spironolactone (2)

A

Hyperkalaemia

Gynaecomastia

45
Q

Sulphasalazine (6)

A
Rashes
Oligospermia
Headache
Heinz body anaemia 
Megaloblastic anaemia
Lung fibrosis