Side effects Flashcards
Omeprazole (5)
Hypomagnesaemia Increased risk c.diff infection Microscopic colitis Hyponatraemia Osteoporosis
Adenosine (8)
Chest pain Flushing Abdo discomfort Headache Hypotension Dry mouth Dyspnoea Arrhythmias
Amiodarone (11)
Hypothyroidism Hyperthyroidism Corneal deposits Pulmonary fibrosis Liver fibrosis Photosensitivity Slate grey appearance Bradycardia Lengthens QT Optic neuritis Increased risk idiopathic intracranial hypertension
Digoxin (4)
Yellow green vision
Gynaecomastica
Anorexia
Confusion
Digoxin toxicity (10)
Nausea Vomiting Diarrhoea Abdo pain Headache Dizziness Confusion Delirium Vision - blurred, yellow Cardiac - irregular, VT, VF, sinoatrial block, atrioventricular block
Ciprofloxacin (5)
Increases INR Tendinitis Tendon rupture Lowers seizure threshold Lengthens QT interval
Nitrofurantoin (2)
Hepatitis
Hepatic failure
Trimethoprim (4)
Isolated increase in creatinine
Rashes
Pruritic
Suppression of haematopoiesis
Amitriptyline (10)
Hyponatraemia Abnormal LFTs Leukopenia Thrombocytopenia Drowsiness Dry mouth Blurred vision Constipation Urinary retention Overflow incontinence
Sertraline (7)
Hyponatraemia GI bleed QT interval prolongation Mania Serotonin syndrome Duodenal ulcer Erectile dysfunction
Amlodipine (5)
Peripheral oedema Nausea Dizziness/postural symptoms Palpitations Flushing
Ramipril (6)
Dizziness/postural symptoms Nausea/vomiting Diarrhoea Chest pain Weakness Angioedema
Verapamil (4)
Constipation
Hypotension
Bradycardia
Flushing
Carbamazepine (8)
Decreased INR Dizziness + ataxia Drowsiness Headache Visual disturbance Steven Johnson syndrome Leukopenia + agranulocytosis Hyponatraemia secondary to SIADH
Phenytoin (9)
Cerebellar syndrome Gingival hyperplasia Decreased INR Peripheral neuropathy Megaloblastic anaemia Osteomalacia Lymphadenopathy Dyskinesia Dupuytren's contracture
Sodium valproate (9)
Increases INR Weight gain Nausea Alopecia Ataxia Tremor Hepatotoxicity Pancreatitis Thrombocytopenia Hyponatraemia
Chlorpromazine (typical) (15)
Parkinsonism Acute dystonia Akathisia Tardive dyskinesia Increased risk stroke/VTE Dry mouth Blurred vision Urinary retention Constipation Sedation Weight gain Increased prolactin Impaired glucose tolerance Neuroleptic malignant syndrome Prolonged QT
Clozapine (atypical) (9)
Agranulocytosis Hyperglycaemia QT interval prolongation Sepsis Idiopathic hyperthermia Weight gain Hypersalivation Increased prolactin Extrapyramidal side effects
Finasteride (4)
Erectile dysfunction
↓ libido
Ejaculation problems
Gynaecomastica
Tamulosin (4)
Dizziness
Postural hypotension
Dry mouth
Depression
Beta blockers (10)
Bronchospasm - avoid w/ asthma Erectile dysfunction Constipation Dizziness/postural symptoms Dry mouth Cold hands + feet Vivid nightmares Tiredness Exacerbates plaque psoriasis Insomnia ↓ hypoglycaemic awareness
Metformin (4)
Lactic acidosis
GI disturbance
Diarrhoea
Bloating
DPP4-inhibitors (gliptins) (3)
Hypoglycaemia
GI upset
Pancreatitis
GLP-1 analogues (atide) (2)
Hypoglycaemia
GI upset
Acarbose (2)
Flatulence
GI disturbance
SGLT2 (2)
Increased risk UTIs
Necrotising faciitis of genitalia and perineum
SU (azide) (4)
Hypoglycaemia
↑ weight
SIADH
Cholestatic liver dysfunction
Thiazolidinediones (6)
Fluid retention ↑ weight Worsening heart failure Liver dysfunction Fractures Bladder cancer
Bendroflumethiazide (7)
GI upset Headache Dizziness/postural symptoms Numbness/tingling Blurred vision Hypokalaemia Hyponatraemia
Furosemide (7)
Sensorineural hearing loss Hypocalcaemia → osteoporosis Hypotension Hyponatraemia Renal impairment Gout Hyaline casts in urine
Ciclosporin (8)
Gum hypertrophy Hypertrichosis Hypertension Hyperkalaemia Hyperglycaemia Hepatotoxicity ↑ risk idiopathic intracranial hypertension SCC or BCC
Metoclopramide (4)
Can induce oculogyric crisis - dystonic reaction in young women
Galactorrhoea
Raised prolactin
Extrapyramidal effects
Rotigotine (parkinsons) (5)
Impulse control disorder Pathological gambling Hypersexuality Binge eating Compulsive shopping
Ethambutol (4)
Blurry vision
↓ visual acuity
Colour blindness
Optic neuritis
Isoniazid (4)
Drug induced lupus
Peripheral neuropathy
Hepatitis
Agranulocytosis
Pyrazinamide (4)
Hyperuricemia → gout
Arthralgia
Myalgia
Hepatitis
Rifampicin (2)
Hepatitis
Orange bodily secretions
Allopurinol
Bone marrow suppression
Azathioprine (4)
Bone marrow depression
Nausea/vomiting
Pancreatitis
↑ risk non melanoma skin cancer
Methotrexate (8)
Bone marrow suppression Anaemia Leucopenia Agranulocytosis Thrombocytopenia Fibrosis in liver + lung Mucositis Pneumonitis
Prednisolone (11)
Insomnia Cushings syndrome Hirsutism Osteoporosis Avascular necrosis of femoral head Mania Depression Psychosis Peptic ulceration Acute pancreatitis Proximal myopathy
Sildenafil (4)
Headaches
Facial flushing
Dyspepsia
Blue green tingeing of vision
Statin (2)
Myopathy - myalgia, myositis, rhabdomyolysis, ↑ CK
Liver impairment
Spironolactone (2)
Hyperkalaemia
Gynaecomastia
Sulphasalazine (6)
Rashes Oligospermia Headache Heinz body anaemia Megaloblastic anaemia Lung fibrosis
