T-cells in Covid-19

Question 1

Do people infected with SARS-CoV-2 develop specific T-cells?

Answer 1

Yes, but immunity isn’t a 100%

Question 2

What does “cross-reactive SARS-CoV-2-specific T-cells” mean?

Answer 2

People who were previously infected with SARS virus have a cross reaction and have an immune response against Covid-19
Cross-reactive T-cell response is possible thanks to the fact that Covid-19 is part of a big virus sub-family
This means that there is a lot of homology and even same genetic sequences in the virus sub-family

Question 3

Which is better in Covid-19 immune response: antibodies or specific T-cells?

Answer 3

It is better to have antibodies because they can attack the pathogen before we get sick whether T-cells need a first infection to then protect, but in any case the best immune response is having both response against a pathogen

Question 4

What does early T-cell activation in Covid-19 couple to?

Answer 4

Early T-cell activation in COVID-19 is coupled to the presence of SARS-CoV-2-specific T-cells
It is shown that people who have early T-cell response to Covid-19 infection also have early antibody activation

Question 5

What does SARS-CoV-2-specific T-cells generate?

Answer 5

SARS-CoV-2-specific T-cells generate a broad, robust and poly-functional response in most individuals with convalescent COVID-19 (2-3 months after infection)

Question 6

How is it possible that SARS-CoV-2-specific T-cells are present in certain seronegative subjects?

Answer 6

Due to cross-reactive T-cells

Question 7

What auto-inflammatory/immune reaction happened in rare cases of Covid-19 trial vaccines?

Answer 7

Rare cases have shown in Covid-19 trial vaccines: the used protein to create the vaccine cross-reacted with hypocretin neurons causing narcolepsy in individuals => T-cells started to kill those neurons

Question 8

How are the symptoms of most people infected with Covid-19?

Answer 8

Most people infected by the disease have mild symptoms