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SFM Immuno > T cells immunity > Flashcards

T cells immunity Flashcards

1
Q

What do mature native T cells have on their cell surface?

A 
CD4 OR CD8 
CD28
MHC Class I 
TCR complex (w/ CD3 molec & zeta)
LFA-1 & VLA-4 adhesion molecules
CCR7
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2
Q

What is the chemokine receptor on T cells?

A

CCR7

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3
Q

TCR complex

A

CD3 molec & zeta

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4
Q

What cells do CD4 T cells activate?

A

B cells & macrophages

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5
Q

Lymph node migration of naive T cells

A

L selectin, LFA-1, CCR7
to
L selectin ligand, ICAM-1, CCL19/21

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6
Q

Peripheral tissue migration of activated (effector & memory) T cells

A

E/P selectin ligand, LFA-1 & VLA-4, CXCR3
to
E/P selectin, ICAM or VCAM, CXCL10

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7
Q

CD28

A

signal transduction (co-stimulation)

bids CD80/B7 from APCs

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8
Q

CD3

A

signal transduction by TCR complex

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9
Q

CTLA-4

A

binds CD80/B7 from APCs, inhibition of T cell signaling

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10
Q

PD-1

A

binds PDL-1/2 on APCs, inhibition of T cell signaling

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11
Q

LFA-1

A

binds ICAM-1 on APC & endothelial cells, signal transduction & adhesion

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12
Q

CD40L

A

on T CELLS!

upregulated expression when binds to CD40 on APCs/B cells

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13
Q

ITAM

A

motif activated by TCR, works thru Zap-70 & PLCy1

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14
Q

CD25

A

receptor on T cell for IL-2a cytokine

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15
Q

IL-2

A

from activated T cells

binds IL-2R (low affinity receptor)

T cell proliferation & survival

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16
Q

IFN-y

A

from CD4/CD8 T cells & NK cells

activates MOs

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17
Q

IL-4

A

from CD4 T cells & mast cells

causes B switching to IgE

18
Q

IL-5

A

from CD4 T, mast cells, lymphoid cells

activates eosinophils

19
Q

IL-17

A

from CD4 T cells

stimulates acute inflammation

20
Q

IL-22

A

from CD4, NK cells

maintains epithelial barrier

21
Q

TGF-B

A

from CD T cells

inhibits T cell activation, promotes T reg cells

22
Q

CD69

A

expressed on T cells after binding Ag (now activated) to S1PR

impairs migration of T cell so stuck in node

23
Q

Cytokines for Th1 cell develop

A

IL-18, IL-12

24
Q

Cytokines for Th2 cell develop

A

IL-4

25
Q

Effector T cells

A

Th1, Th2, Th17, Tfh

26
Q

Th1 secretion

A

IFN-y (to MOs)

27
Q

Th2 secretion

A

IL-4, 5, 13 to eosinophils (v allergies)

28
Q

Th17 secretion

A

IL-7, 22 to neutrophils (inflammation)

29
Q

Tfh secretion

A

IL-21 & IFN-y, to B cells for Ab production v extracell pathogens

30
Q

T reg cells

A

CD4+ T cells

need IL-2 & TGF B

always express CTLA-4 & CD25

transcrip factor FOXp3

secrete TGF-B & IL-10

31
Q

Gamma delta T cells

A

mostly in epithelial boundaries (gut mucosa)

32
Q

Th1 cells

A

activate DCs, MOs & NKs (via IL-2 & IFN-y)

novel TF T-bet

IFN-y to activate B cell switching & complement binding

33
Q

IFN-y

A

stimulates class II & B7 expression

34
Q

Th2 cells

A

proliferate in response to IL-4

novel TF GATA-3

secrete IL4, 5, 13

**stimulate IgE, mast cell & eosinophils, & alternative MOs

35
Q

Th17

A

grow in response to IL-1 & IL-6

induce inflammation/leukocyte recruitment via IL-17 & IL-22

novel TF RORyt

36
Q

Cytotoxic CD8+ cells

A

TCR recognizes class I MHC

kill cells w/ intracell pathogens or tumor cells

depend on Th1 (IL-2) for proliferation/cloning

37
Q

CD8 cell killing mechanisms

A

granular proteins (granzymes & perforin)

FasL/Fas induction of apoptosis

38
Q

NK cell surface markers

A

CD16 & CD56

39
Q

memory T cells

A

both CD4 & CD8, need re-activation for effector function

can respond in peripheral tissues, faster response than naive T cells

**need IL-7 & IL-15 for survival

40
Q

Mechanisms of Evasion (by pathogens)

A

inhibit fusion w/ phagosome, inhibit Ag presentation, inhibit proteasome activity, produce IL-10 to block MO/DC activation, inhibit production of cytokine receptors

SFM Immuno (4 decks)

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