Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Immunology. 9. B and T Cells. > T Cells and B Cells. > Flashcards

T Cells and B Cells. Flashcards

1
Q

Where do all T cells mature?

A

In the thymus (T stands for thymus).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What happens to T cells once they arrive in the thymus?

A

They divide very rapidly and undergo somatic rearrangement.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Will T cells all express the same TCR?

A

No, the amount of diversity between the different TCRs that a T cell can express is huge.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the only somatic cells where somatic gene rearrangement takes place?

A

B and T cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What must happen to B and T cells before they can function?

A

They must be educated.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are naive T cells also known as?

A

As thymocytes.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the name of the first step of T cell education?

A

Positive selection.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What occurs during the positive selection of T cells?

A

T cells bind to a self MHC and learn to recognise it.

This means that the T cell can recognise the MHC complexes of the body.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

During positive selection what happens to the T cells that do not bind to a self MHC?

A

They are killed.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is the 2nd step of T cell education?

A

Negative selection.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What occurs during the negative selection of T cells?

A

The T cell tries to bind to a self antigen.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

During negative selection, what happens to T cells that form strong bonds with self antigens?

A

They will be killed.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What bonds do we want naive T cells to form self antigens?

A

Very weak bonds that are not strong enough to form an immune response.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What happens if the negative selection step of T cell education fails?

A

We can get an autoreactive T cell.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How long does T cell education in the thymus take?

A

Around 4-5 days.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What will be expressed by T cells that survive T cell education in the thymus?

A

CD-4 or CD-8 molecules.

17
Q

What CD molecule is expressed by all T cells?

A

CD-3.

18
Q

What are the CD molecules that can be expressed by the 2 types of T cells as they leave the thymus?

A

CD-3+ and CD-4+.

CD-3+ and CD-8+.

19
Q

What happens to T cells once they have acquired the CD molecules?

A

They can migrate to the secondary lymphoid tissues.

20
Q

Do naive T cells leave the thymus?

A

Yes.

Naive T cells enter the secondary lymphoid tissues.

21
Q

Where do B cells mature in birds?

A

In the bursa.

22
Q

Where do B cells mature in mammals?

A

In the bone marrow and in the Peyers patches.

23
Q

What are Peyers patches?

A

The mammalian equivalent of a bursa.

24
Q

Where in the body are peyers patches found?

A

All over the body.

25
Q

What happens as the B cells mature in the bone marrow?

A

They undergo gene rearrangement so they can display a BCR.

26
Q

What is the first step of B cell education?

A

Negative selection.

27
Q

What occurs during the negative selection of B cells?

A

They are taught not to attack self antigens.

Any self reactive B cells undergo apoptosis.

28
Q

Do B cells undergo positive selection?

A

No.

29
Q

What happens to B cells once they have matured in the bone marrow?

A

They travel to secondary lymphoid tissues such as Peyers patches.

30
Q

Can Peyers patches be thought of as primary and secondary lymph tissue?

A

Yes, but they mainly function as secondary lymph tissue.

31
Q

What CD molecule is always expressed by B cells?

A

CD-79.

32
Q

What CD molecules are expressed by T cells?

A

CD-3+.

CD-4+.

CD-8+.

33
Q

What CD molecules are expressed by helper T cells?

A

CD-3+.

CD-4+.

34
Q

What CD molecules are expressed by cytotoxic T cells?

A

CD-3+.

CD-8+.

35
Q

What 3 cell types make up lymphocytes.

A

Natural killer cells.

B cells.

T cells.

36
Q

What are the only lymphocytes to function in the innate immune system?

A

Natural killer cells.

37
Q

What lymphocytes do not mature in the lymph tissue?

A

Natural killer cells.

38
Q

What lymphocytes do not have receptors for antigens?

A

Natural killer cells.

Immunology. 9. B and T Cells. (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions