T cells Flashcards
1
Q
Th1
A
Activated by IL12 and INF Y
IFN Y & IL2
Macrophage activation (via CD40/CD40L)
Granulomas
CTLs and memory w/ IL2
2
Q
Th2
A
Activated by IL2 and IL4
IL4, 5, 13
Eosinophil and mast cell activation w/ IL5 (helminths)
Class switching w/ IL4, IL13
3
Q
Th17
A
Activated by IL1, 6, 23, TGFB
IL17, 22
Neutrophil recruitment w/ IL17
Activate epithelial cells and AMP
4
Q
Tregs (FOXP3, CD25)
A
Induced by cytokines or cells that strongly recognize self
Activated by IL2 and TGFB
Downregulate immune response, inhibit other cells w/ CTLA4, TGFB, IL10
5
Q
Tfh
A
Activated by TGFB
IL4, IL21
Class switching, antibody production, macrophage activation
6
Q
CTLA-4
A
Binds to B7/CD80 on other T cells, stop second signal
7
Q
PD-L1
A
Prevents APCs from getting killed by T cells
