Immune Disorders Flashcards
1
Q
HLA class II deficiency
A
CIITA issues
1
Q
Chediak-Higashi syndrome
A
Defect in LYST (granule trafficking gene)
Pigmentation, bleeding, neutropenia
Recurrent bacterial infections especially in skin and respiratory tract
2
Q
HLA class I deficiency
A
TAP and tapasin
3
Q
DiGeorge’s syndrome
A
Very little thymus tissue → reduced T-cells and reduced B-cell function
4
Q
SCID - IL-7
A
No T cells
5
Q
SCID - JAK3
A
No T or NK cells
6
Q
SCID - common Y chain
A
No T or NK cells
7
Q
SCID - ADA
A
No T, NK or B cells
8
Q
SCID - CD3
A
No T cells
