T Cells

Question 1

Th1

Answer 1

Activates - blood monocytes that become ‘Angry’ macrophages. (IL-1 and TNF-alpha)
- Activates killer T-cells
- T1 and T17 are proinflammatory

Question 2

T cell conditions

Answer 2

° have to be present the site of infections diseases

Question 3

Cytokines

Answer 3

• Short-range mediators made by any cell that affect the behavior of the same or another cell (pro-inflammatory)
• IL-1, TNFalpha, IL-12
• Related to Th1

Question 4

Lymphokines

Answer 4

• Short-range mediators made by lymphocytes, which affect the behavior of the same of another cell.
• Cytokine subsets.
• Ex : IL-2, IFNgamma, IL-4, IL-5, IL-10

Question 5

Chemokines

Answer 5

• Small (6-14 kD) short range mediators made by any cell.
• Primarily cause inflammation.
• Ex : MIP-1 to -4, RANTES, CCL28, CXCL16, Eotaxin, IL-8

Question 6

Th17

Answer 6

• new and heavily researched
• Makes IL-17
• Similar to Th1
• Causes inflammation
• Related to autoimmune diseases (like Th1)
• Develops immunity against the bacterial and yeast pathogens

Question 7

Th2

Question 8

Tfh

Question 9

Treg

Question 10

CTL

Answer 10

• Kiss of death/ lethal hit
• apoptosis
• rapid DNA fragmentation and nuclear collapse
• death receptors (CD95/Fas- CD95L) on target
• Lytic granules - proteazes called granzymes, perforins
• Th1 - activates IL-2
• These turns in memory cells

Question 11

CD - important surface markers

Answer 11

CD3 - all T-cells
CD4 - on T helpers
CD8 - on CTL
C20 - B cells

Question 12

MHC restriction, part I