t cells 1

Question 1

what is the genetic condition that causes no adaptive immunity

Answer 1

SCID

Question 2

what drug is used to model the importance of t cells vs b cells

Answer 2

fingolimod

Question 3

where are t cells generated

Answer 3

bone marrow

Question 4

where do t cells mature

Answer 4

thymus

Question 5

what does the maturation process allow for the generation of and why is this important

Answer 5

extensive range of t-cell receptors
allows the recognition of millions of amino acid sequences as being foreign which leads to an immune response

Question 6

what are t cells effector function
(hint - 4 functions)

Answer 6

killing cells directly
helping b cells make antibodies
producing lots of cytokines
activating other cells in the immune system

Question 7

what do t cells respond to

Answer 7

peptides presented in MHC molecules

Question 8

what type of cells are specialised t cells produced from

Answer 8

a naive cell

Question 9

what type of t cells is cytoxic

Answer 9

CD8+ t effector cell

Question 10

what type of t cell is a helper t cell

Answer 10

CD4+ t effector cell

Question 11

where will the types of t cells vary

Answer 11

in different organs

Question 12

how will t cells recognise an antigen

Answer 12

only through their t cell receptors when the antigen is bound

Question 13

what is necessary to be present for a TCR to recognise an antigen

Answer 13

only when it is bound within a MHC molecule

Question 14

why do can t cells only recognise antigens under certain conditions

Answer 14

as without control there can be a lot of damage to the cells

Question 15

what else can the TCR recognise

Answer 15

infected cells

Question 16

what are the two domains of the tcr

Answer 16

constant and variable

Question 17

what is the name of the region that makes contact with the antigen

Answer 17

the complementary determining region

Question 18

how are the t cell receptors so diverse and show does it work

Answer 18

vdj recombination
the genes that make up the tcr gene locus rearrange to make many receptors

Question 19

what is combination diversity

Answer 19

where you get range from the different combinations of gene segements

Question 20

what is junctional diversity

Answer 20

where you get range from the addition of nucleotides after recombination occurs

Question 21

where are the most variable regions of the tcr and why

Answer 21

where the segments join
junctional diversity where more nucleotides are added when the segments are joined

Question 22

what is antigen presentation

Answer 22

where an MHC molecule will bind to proteins from viruses and bacteria and present them to t cells