T Cell Receptor Complex, CD4 and CD8 Corecpetors

Question 1

TCR strucutre

Answer 1

All T cells have many copies of identical TCR on their surface. composed of 2 diff polypeptides called alpha and beta chain held together by disulfide bond. each chain has constant and variable domain

Question 2

are TCR part of the Ig superfamily.. why

Answer 2

each chain has diff primary strucutre, nut composed of 2 Ig-like domains therefore yes

Question 3

fn of constant domains

Answer 3

to support the variable domains and attach the TCR to the cell

Question 4

describe constant domains of alpha and beta chains

Answer 4

the same on all TCR of all T cells

Question 5

describe variable domains of alpha and beta chain

Answer 5

of any one TCR they are diff from eaach other. on any one naive T cell, all of the TCR are identical. any two naive T cells will have identical constant domains but diff variable domains

Question 6

CD3 strucutre

Answer 6

one Ig-like domain, a transmembrane protein and a cytoplasmic region