T Cell Mediated Immunity/Effector

Question 1

TCR

Answer 1

recognizes MHC associated peptide antigens, which will aid in activating the mature, naive cell to an effector cell

Question 2

CD4/CD8

Answer 2

Co-receptors that recognize MHC molecules on the APC and help the TCR complex to deliver activating signals

Question 3

CD3

Answer 3

surface molecule responsible for signal transduction by the TCR complex. Consists of three polypeptide chains, delta, epsilon, and zeta. Zeta chain contains ITAMS (regions of signaling proteins that are phosphorylated on tyrosine residues and become docking sites for other tyrosine kinases)

Question 4

CD25

Answer 4

alpha chain of the IL-2 receptor. By adding this to IL-2Rbyc the alpha chain will increase the affinity of the receptor and IL-2 will bind more readily to promote T-cell proliferation and differentiation

Question 5

CD28

Answer 5

costimulator of signal transduction which will bind to B7 on APCs. Costimulatory signaling is necessary in activating naive, mature T cells, but not effector or memory cells.

Question 6

CTLA-4

Answer 6

this is an inhibitor which binds to B7 of APCs. It will prevent the costimulatory signal and thereby prevent activation of a naive, Mature T cell