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SFM Immuno Exam 1 Flashcards

1
Q

TNF, IL-1, chemokines

A

Function: pro-inflammation

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2
Q

INF-a, IFN-B

A

resistance to viral infection

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3
Q

IFNy

A

macrophage activation

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4
Q

IL-12

A

IFNy production (by NK cells and T cells)

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5
Q

IL-15

A

Proliferation of NK cells

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6
Q

IL-10, TGF-B, IL-4

A

control of inflammation (anti-inflammatory)

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7
Q

IL-1, TNFa, IL-6

A

secreted by Tissue macrophage, enter bloodstream and produce systemic effects (acute phase response)

  • fever (IL-1, TNFa, IL-6)
  • induction of acute phase proteins (IL-6, IL-1, TNFa)
  • althralgia/myalgia (TNF-a)
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8
Q

IL-2

A

Growth factor for T cells, makes resistant to apoptosis

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9
Q

IL-8

A

chemokine for neutrophils, stimulate conformational changes in ICAM-1 and VCAM1

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10
Q

MCP-1

A

chemokine for monocytes, stimulates conformational changes in ICAM-1 and VCAM1

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11
Q

PAMPS

A

pathogen associated molecular proteins

recognized by PRR (pattern recognition receptors)

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12
Q

TLR2/TLR6

A

recognizes gram positive bacteria

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13
Q

TLR4

A

recognizes gram negative bacteria

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14
Q

CR1

A

copmlement receptor type 1: on surface of macrophage or neutrophil, binds C3b after it has bound to pathogen survace

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15
Q

Th1 (T helper 1)

A

cells control against intracellular pathogens

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16
Q

Th2 (T helper 2)

A

control responses against extracellular pathogens,

also promote production of antibodies by B cells

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17
Q

Dendritic cells direct diff of T. cells

A

into T helper 1 cells or T helper 2 cells

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18
Q

TLR3

A

double stranded (viral) RNA

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19
Q

TLR5

A

flagella

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20
Q

TLR9

A

unmethylated CpG DNA

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21
Q

C1 (CP)

A

initiates classical pathway

22
Q

C1q (CP)

A

binds to Fc portion of Ab that has antigen bound to apoptotic cells and cell surfaces

23
Q

C1r (CP)

A

serine protease, cleaves C1s to make active

24
Q

C1s (CP)

A

serine protease, cleaves C2 and C4

25
C4
covalently binds to microbe to activate complement. C4b binds C2 for cleavage by Cls
26
C2
C2 serine protease and functions as active enzyme of C3 and C5 convertases to cleave C3 and C5
27
MBL (LP)
agglutinin, opsonin, complement fixing
28
MASP1 (LP)
forms complex with MASP2 and collectins or ficolins, activates MASP2-3
29
MASP2 (LP)
forms complex with lectins esp. ficolin-2. | - cleaves C4 and C2
30
CP and LP C3 convertase
C4bC2a - after cleaving C3 (to C3b and C3a - opsonin) - forms C4bC2aC3b (C5 convertase)
31
CP and LP C5 convertase
C4bC2aC3b | - cleaves C5 to C5a (opsonin) and C5b (activates MAC)
32
AP C3 convertase
C3bBb
33
AP C5 convertase
C3bBbC3b
34
Complement regulatory proteins
prevent complement system from activating on human cells (for lysis)
35
C1 inhibitor (C1 INH)
complement regulatory protein | inactivates C1r, C1s, MASP1, MASP2
36
MCP
complement regulatory protein | cofactor for factor 1 mediated cleavage C3b and C4b
37
DAF
complement regulatory protein | destabilizes C3/C5 convertases of CP and AP
38
CR-1
complement regulatory protein | cofactor for facor 1 mediated cleavage of C3b and C4b
39
C4 Binding protein (C4BP)
complement regulatory protein | binds to C4b, decay accelerating and cofactor activity
40
Factor H
complement regulatory protein | Binds to C3b - has decay accelerating activity of AP c3 and C5 convertases and cofactor activity
41
CD59
complement regulatory protein | blocks C9 association 2 C5b-8 to prevent C5b-9 form on host cells
42
S protein
vitronectin binds to C5b-7, inhibis C9 polymerization
43
Disease from C1, C2, C4 Deficiency
immune complex disease (all pathways)
44
Disease from C3 Deficiency
susceptibility to capsulated bacteria
45
Disease from C5-C9 Deficiency
susceptibility to Neisseria (no MAC)
46
Disease from Factor 1 Deficiency
susceptibility to capsulated bacteria
47
Disease from Factor D, properdin (Factor P) Deficiency
susc. to capsulated bacteria and neisseria, no immune complex disease
48
Disease from DAF, CD59 Deficiency
Autoimmune-like conditions including PNH
49
Disease from C1-INH Deficiency
hereditary angioedema - due to buildup of bradykinin | C1-INH inactivates plasma kallikrein, cleaves plasma kininogen to produce bradykinin
50
systemic lupus - Glomerulonephritis
local activation of complement and production of C3a and C5a, recruits inflammatory cells and further aggravates - MAC mediated injury to glomerulus due to overactive complement

SFM (11 decks)

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