T-Cell Mediated Immunity (Ch. 5) Flashcards
Naive T-cells recognize AG in the ________ and this initiates proliferation of T-cells to CD4 or CD8
LN
T-cells react with APC and then produce what which starts differentiation into effector T-Cells
IL-2(autocrine)
Memory leukocytes respond how to Ag
Rapidly
What do adhesion molecules do
Strengthen binding of T-Cell to APC
What do costimulators do
Increase responsiveness to APC
What is signal 1
Ag. Recog. Via MCH:TCR
What is signal 2
Costimulation via B7:CD28
What are the components fo CD3
ITAMS and DE/GE
What is CD4/CD8 responsible for in T-cells activation
Signal transduction
What is CD 28 responsible for and what does it bind to
Costimulation
Binds to B7 (CD80/86)
What is the role of CTLA-4 and what does it bind to
Inhibition
Binds to B7
What is the role of PD-1 and what does it bind to
Inhibition
Binds to PD-L1
What is the role of LFA-1 and what does it bind to
Adhesion
binds to ICAM - 1
Full activation of T-Cells requires what
Costimulation via CD28:B7
What is CD 69
T-cell marker for cell migration
B7-1 (CD80) or B7-2 (CD86):CD28 =
Activation of naive T cells
B7-1 (CD80) or B7-2 (CD86):CTLA-4 =
Inhibition of reg. T-cells
ICOS-L:ICOS =
Activation of FThC
PD-L1 and PD-L2:PD-1R =
Inhibition
What does CD40:CD40L do
Increases prod of IL-12 which causes an increase of IL-2 and helps stimulate T-Cell proliferation
What brings LCK to the ITAM to begin pathways within T-Cells
CD4/CD8
What is Zap-70 and what does it do
Tyrosine kinase, phosphorylates PCLy1 and begins the pathway
Is located at docking sites on ITAMS
What does calcineurin do
Removes phosphate from cytoplasmic NFAT, enabling it to move to nuc.
What does Cyclosporible do
Inhibits calcineurin phosphatase activity and supresses NFAT
Where is NFKB originally and what is it bound to
In the cytoplasm, bound to IKB before it is cleaved and activated
What receptors for IL-2 do naive T-cells have
IL-2RByc (low affinity)
After co-stimulation by B7:CD28, T-cells make what and express what receptor
Make IL-2 (autocrine) and express IL-2RaByc
IL-2Ra is also called what?
CD25
