T Cell Med. Immunity

Question 1

CD+ Th1

Answer 1

Acti. IL-12

Question 2

Mature Naive T cell secrete

Answer 2

CCR7

Question 3

T cell activation

Answer 3

1) TCR/HLA Antigen recognition
2) CD40L on T cell binds to CD40 on DC
3) DC expresses B7 (enhances)

Question 4

Downstream activation of T Cells

Answer 4

Involves ITAMs and act. of ZAP-70 with zeta chain

Question 5

CD69

Answer 5

Upon T cell activation with appropriate antigen, sequesters T cell as this chemokine attaches to S1PR(autocrine signaling)

Question 6

CD4+ Treg cells

Answer 6

Influenced by IL-2, IL-10 and TGF-B. Expresses CTLA-4 and CD25.

Question 7

Difference betweenn CTC vs THC is

Answer 7

CTC expressed FasL vs THC expresses CTLA-4

Question 8

Effector t cell doesnt need

Answer 8

costimulator B7(CD80)-CD28

Question 9

Th1

Answer 9

Proliferate with help of IL-12 and IL-2. Secretes IFN-Y and TNF-alpha.

Classical macrophage activ. and acts on intracellular pathogens such as in chronic inflammation and autoimmunity.

Question 10

Th2

Answer 10

Proliferate in response to IL-4 from mast, basophil and surrounding th2 cells. Secrete IL-4, IL-5 and IL-13.

Involved in eosinophil, mast cell and ALTERNATIVE macro. activation. Defends against helminths due to allergy.

Question 11

Th17

Answer 11

Proliferate in response to IL-1 and IL-6 from DCs.
Secretes IL-17 and IL-22.

Involved in neutrophil act. against extracellular bacteria and fungi. Involved in autoimmunity and inflammation.

Secrete IL-17 and IL-22

Question 12

IL-5

Answer 12

Increase eosinophil migration

Question 13

IL-13

Answer 13

Inc. production of mucus in epithelial cells

Question 14

IL-17

Answer 14

Inflammatory. Recruitment of pro-inflammatory leukocytes.Antimicrobial peptide production.

Question 15

IL-22

Answer 15

Promotes regenerative responses within epithelial barrier. Antimicrobial peptide production.

Question 16

CD4+ Treg

Answer 16

Express CTLA-4 and CD25