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Malignant Hematology > T Cell Lymphomas > Flashcards

T Cell Lymphomas Flashcards

1
Q

ALK+ Anaplastic large cell lymphoma has what prognosis?

A

Good

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2
Q

Anaplastic large cell lymphoma in general has a ____ prognosis compared to PTCL?

A

Much better

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3
Q

GATA-3 denotes what prognosis in PTCL?

A

Poor

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4
Q

Initial amnagement of PTCL

A

CHO(E)P

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5
Q

Initial management of PTCL that is CD30+

A

BV-CHP

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6
Q

Who should not get etoposide added to inital management in PTCL?

A

Age >60

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7
Q

When should we take PTCL to autoSCT?

A

First CR

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8
Q

Treatment for localized nasal NK/T cell lymphoma in an unfit patient?

A

RT alone

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9
Q

Treatment for localized nasal NK/T cell lymphoma in a fit patient?

A

Sequential or concurrent chemo then RT
SMILE then RT
LVP then RT

VIC+RT
Cis+RT then VIPD

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10
Q

Treatment for disseminated NK/T-cell lymphoma? (2)

A

SMILE +/- RT
DDGP (Cisplatin, Dex, Gem, Asp)

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11
Q

Treatment for breast implant assocaited anaplastic LCL?

A

Remove the implant

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12
Q

MoA of Mogamulizumab?

A

Anti-CCR4 mAB

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13
Q

1L Management of early stage CTCL? (4)

A

Steroids
Bexarotene
PUVA
Localized RT

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14
Q

2L treatment of early stage CTCL? (3)

A

Total skin electron
Interferon-alpha
MTX

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15
Q

1L treatment for advanced CTCL?

A

Steroids, PUVA, RT
MTX
ECP
Gem
Doxil

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16
Q

Preferred front line regimen for ALK+ ALCL?

A

BV-CHP

17
Q

Treatment of unicentric Castleman’s diseae?

A

Surgical resection of the involved LN

18
Q

What is the definition of unicentric vs multicentric Castleman’s disease?

A

Unicentric only involves a single enlarged LN.
Multicentric involves multiple, usually has severe symptoms and HHV-8 infection

19
Q

What infection is associated with multicentric Castleman’s disease?

A

HHV-8

20
Q

Treatment of active Multicentric Castleman’s disease with organ failure?

A

R-CHOP
R monotherapy

21
Q

Treatment for multicentric Castleman’s disease without organ failure in patients who are HIV negative and HHV8 negative?

A

Siltuximab

22
Q

Treatment for multicentric Castleman’s disease without organ failure in patients who are HIV+ and/or HHV-8+?

A

Rituximab

23
Q

3 criteria for active Castlemans disease?

A

Fever
Increased CRP >20
At least 3 MCD symptoms: LAD, splenomegaly, edema, effusion, ascites, cough, nasal obstruction, xerostomia, rash, neuro sx, jaundice, AIHA

24
Q

Immunophenotype of Adult T-cell leukemia/lymphoma?

A

CD2+, CD3+. CD4+, CD5+,
CD7-, CD8-
CD25++, CD29+
Negative for CD10, 19, 20)

25
Q

What is Erdheim Chester disease?

A

Multisystem histiocyte disorder that leads to infiltration of organ systems. Usually has osteosclerotic lesions in long bones.

26
Q

Treatment of Erdheim Chester disease with BRAF V600E mutation?

A

vemurafenib

27
Q

Patient presents with a pleural effusion, ascites, generalized lymphadenopathy, fever, and hepatosplenomegaly. LN biopsy shows a CD3+, CD4+, CD7+, CD8+ lymphoma. Diagnosis?

A

Aitl

28
Q

Preferred treatment for AITL (4)

A

Bv-CHP (for CD30+)
CHOEP
CHOP
DA-EPOCH

29
Q

Treatment for primary cutaneous ALCL that is localized

A

Surgery +/- ISRT or ISRT alone

30
Q

Treatment for primary cutenaous ALCL taht is multifocal but no visceral disease

A

Bv

31
Q

Treatment of ERdheim chester disease with a MAPK mutation?

A

Cobimetinib

32
Q

Treatment of Erdheim Chester disease without any special mutation?

A

Cladribine

Malignant Hematology (13 decks)

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