BMT and CAR-T

Question 1

What HSCT source has higher risk for infection?

Answer 1

Umbilical cord blood

Question 2

What HSCT source has faster engraftment?

Answer 2

PB

Question 3

What HSCT source has higher risk of chronic GHVD

Answer 3

peripheral blood

Question 4

If patient doesn’t have a suitable sibling donor, what is the second best option?

Answer 4

Fully matched unrelated donor

Question 5

What is more preferable? MMUD or haploidentical?

Answer 5

Haploidentical

Question 6

Define G1-4 skin acute GVHD

Answer 6

1: <25% BSA
2: 25-50% BSA
3: >50% BSA
4: Generalized erythroderma and bullous formation and desquamation

Question 7

Define G1-4 Liver acute GVHD

Answer 7

1: Bili 2-3
2: 3-6
3: 6-15
4: >15

Question 8

Define G1-4 GI acute GVHD

Answer 8

1: >500 ml diarrhea
2: >1000 ml +/- N/V
3: >1500 ml
4: Severe abd pain or ileus, or >2L stool

Question 9

Treatment for G1-2 acute skin GVHD

Answer 9

topical steroids

Question 10

Treatment for G2-4 skin acute GVHD

Answer 10

systemic steroids

Question 11

Second line therapy for acute GVHD

Answer 11

ruxolitinib

Question 12

2L treatment for chronic GVHD (2)

Answer 12

Ruxolitinb
Ibrutinib

Question 13

3L for chronic GVHD treatment

Answer 13

Belumosudil

Question 14

Two severe and unique complications of calcineurin inhibitors?

Answer 14

TMA
PRES