T-cell development Flashcards

1
Q

T cells mature in the .

A

thymus

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2
Q

is a type of T cell that functions to maintain specific immune tolerance through the suppression of CD4+ and CD8+ T cell effector function.

A

Regulatory T cell

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3
Q

The is the cell surface receptor on T cells that binds to the antigen-MHC complex.

A

T cell receptor

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4
Q

is the lymphocyte type that is characterized by CD3 and CD28 cell surface proteins.

A

T cells

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5
Q

is a type of T cell that functions to produce cytokines that activate other cells of the immune system.

A

CD4+ T cell

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6
Q

T cells are a subclass of lymphocytes that differentiate from other T cells through the activity of cytokine TGF beta and are involved in down-regulation of effector T cells.

A

Regulatory

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7
Q

The is a type of lymphocyte involved in paracortex hyperplasia of a lymph node.

A

T cell

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8
Q

is a type of T cell that MHC II binds to.

A

CD4+ T cell

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9
Q

is a type of T cell that MHC I binds to.

A

CD8+ T cell

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10
Q

Interleukin-12, released from macrophages, induces the differentiation of T cells to _______ cells.

A

TH1

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11
Q

________ cells are the class of lymphocytes that proliferate during a type IV hypersensitivity reaction.

A

Th1

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12
Q

________ is the cell surface receptor on T cells that binds to B7 on APC’s during the secondary signal in T cell activation.

A

CD28

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13
Q

_______ is a type of T cell identified by the expression of the transcription factor FOXP3.

A

Regulatory T cell

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14
Q

The ________ is a type of lymphoblast that can express CD2, CD3, CD4, CD5, CD6, CD7, CD8, and CD28 receptors.

A

T cell

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15
Q

The is the most abundant lymphocyte in a normal person.

A

T cell

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16
Q

The is the most abundant lymphocyte in a normal person.

A

T cell

17
Q

__________ is a type of T cell that functions to kill virus-infected cells directly.

A

CD8+ T cell

18
Q

___________ is a type of T cell that functions to kill virus-infected cells directly.

A

CD8+ T cell

19
Q

___________ is a type of lymphocyte associated with acute and chronic organ rejection.

A

T cell

20
Q

is a type of T-cell in the lymphoid organs that functions to activate B-cells and make antibodies.

A

follicular CD4+ T helper cell

21
Q

A CD4+ and CD8+ double-positive T-cell are present within the thymic cortex. It binds successfully with MHC I molecules expressed by cortical epithelial cells and travels to the thymic medulla. Which of the following stages in T-cell development did this cell just complete?

A. Positive selection
B. Autocrine stimulation
C. VDJ rearrangement
D. Negative selection
E. Self-tolerance

A

A. Positive selection