B-cell development Flashcards
During B-cell development, a pro-B cell becomes a ________ cell.
pre-B
When immature B-cells in the bone marrow have self-reactive receptors, the cells are lost to _________ .
central tolerance
Immature B-cells leave the bone marrow, becoming transitional B-cells, and complete the maturation process in the …………… .
spleen
.
During B-cell development, a pre-B cell becomes an ……… .
immature B-cell
.
The first immunoglobulin that is
present on an immature B-cell’s surface is …………..
IgM
The early pro-B cell development stage is the starting point of _______ chain recombination.
VDJH
In the fetus, the primary location of B-cell development is in the _________ .
liver
B-cells develop in the ________.
bone marrow.
_________ are two immunoglobulin isotypes expressed on the surface of mature, naive B cells.
IgM and IgD
The most important marker on B-cells is CD ________ .
CD19
(Pre/Pro/Immature) B-cells undergo negative selection.
Immature
____________ are two immunoglobulin isotypes expressed by naive B cells.
IgM and IgD
B cells differentiate into ________ when they encounter an antigen at peripheral lymphoid tissue.
Plasma cells
The presence of _____ on B-cell receptors allow B-cells to leave the bone marrow.
IgD constant region
The two immunoglobulins on the surface of mature B-cells are _____ .
IgM and IgD
(Pro/Pre) -B cells express immunoglobulin in their cytoplasm rather than on their cell surfaces.
Pro
During B-cell development, a hematopoietic stem cell becomes a _______ cell.
Pro-B
The majority of common lymphoid progenitors that remain in the bone marrow become (B/T) ______ cells.
B
______ is a lymphocyte characterized by CD19, CD20, CD21 and CD40 cell surface proteins.
B-cell
Immature B-cells are ready to be exported to the spleen when they express _______ on their membranes.
IgM and IgD
B cells are positive for major histocompatibility complex class(es) (I/ II/ I and II) ______.
I and II
_______ is a cell surface receptor on B cells that binds to CD40L on helper T cells during B cell activation.
CD40
The pre-B-cell checkpoint checks if the is on the cell surface, and if it is not the cell undergoes apoptosis.
pre-B-cell receptor
A researcher is studying cells produced by hematopoietic stem cells. One of the cells that is being studied is a lymphocyte that has CD3 and CD8 receptors on its surface. This type of cell originates from the bone marrow. Which of the following is the location where this cell differentiates to become a mature lymphocyte?
A. Spleen
B. Thymus
C. Lymph nodes
D. Bone marrow
E. Bloodstream
B. Thymus
