B-cell development

Question 1

During B-cell development, a pro-B cell becomes a ________ cell.

Answer 1

pre-B

Question 2

When immature B-cells in the bone marrow have self-reactive receptors, the cells are lost to _________ .

Answer 2

central tolerance

Question 3

Immature B-cells leave the bone marrow, becoming transitional B-cells, and complete the maturation process in the …………… .

Answer 3

spleen
.

Question 4

During B-cell development, a pre-B cell becomes an ……… .

Answer 4

immature B-cell
.

Question 5

The first immunoglobulin that is
present on an immature B-cell’s surface is …………..

Answer 5

IgM

Question 6

The early pro-B cell development stage is the starting point of _______ chain recombination.

Answer 6

VDJH

Question 7

In the fetus, the primary location of B-cell development is in the _________ .

Answer 7

liver

Question 8

B-cells develop in the ________.

Answer 8

bone marrow.

Question 9

_________ are two immunoglobulin isotypes expressed on the surface of mature, naive B cells.

Answer 9

IgM and IgD

Question 10

The most important marker on B-cells is CD ________ .

Answer 10

CD19

Question 11

(Pre/Pro/Immature) B-cells undergo negative selection.

Answer 11

Immature

Question 12

____________ are two immunoglobulin isotypes expressed by naive B cells.

Answer 12

IgM and IgD

Question 13

B cells differentiate into ________ when they encounter an antigen at peripheral lymphoid tissue.

Answer 13

Plasma cells

Question 14

The presence of _____ on B-cell receptors allow B-cells to leave the bone marrow.

Answer 14

IgD constant region

Question 15

The two immunoglobulins on the surface of mature B-cells are _____ .

Answer 15

IgM and IgD

Question 16

(Pro/Pre) -B cells express immunoglobulin in their cytoplasm rather than on their cell surfaces.

Answer 16

Pro

Question 17

During B-cell development, a hematopoietic stem cell becomes a _______ cell.

Answer 17

Pro-B

Question 18

The majority of common lymphoid progenitors that remain in the bone marrow become (B/T) ______ cells.

Answer 18

B

Question 19

______ is a lymphocyte characterized by CD19, CD20, CD21 and CD40 cell surface proteins.

Answer 19

B-cell

Question 20

Immature B-cells are ready to be exported to the spleen when they express _______ on their membranes.

Answer 20

IgM and IgD

Question 21

B cells are positive for major histocompatibility complex class(es) (I/ II/ I and II) ______.

Answer 21

I and II

Question 22

_______ is a cell surface receptor on B cells that binds to CD40L on helper T cells during B cell activation.

Answer 22

CD40

Question 23

The pre-B-cell checkpoint checks if the is on the cell surface, and if it is not the cell undergoes apoptosis.

Answer 23

pre-B-cell receptor

Question 24

A researcher is studying cells produced by hematopoietic stem cells. One of the cells that is being studied is a lymphocyte that has CD3 and CD8 receptors on its surface. This type of cell originates from the bone marrow. Which of the following is the location where this cell differentiates to become a mature lymphocyte?

A. Spleen
B. Thymus
C. Lymph nodes
D. Bone marrow
E. Bloodstream

Answer 24

B. Thymus