SZ biological treatments

Question 1

Name an a-typical antipsychotic

Answer 1

Clozapine

Question 2

Name a typical antipsychotic

Answer 2

Chloroprozamine

Question 3

How do typical antipsychotics work?

Answer 3

-Dopamine antagonists
-Block D2 receptors (bind but don’t simulate) on mesolimbic pathway
-Reduce hallucinations + delusions within a few days. Other pos symptoms take longer

Question 4

How do a-typical antipsychotics work?

Answer 4

-Block D2 receptors, disassociate rapidly so regular dopamine activity
-+ greater affinity for serotonin receptors
-Reduce neg symptoms, cog impairment and pos symptoms

Question 5

Differences between typical and a-typical

Answer 5

-A-typical affects serotonin receptors as well rather than just D2
-A-typical has fewer side effects (e.g no tardive dyskinesia)
-A-typical is second gen anti-psychotics

Question 6

A03 of drug therapy

Answer 6

Crossley et al- Meta-analysis- med significant reduction in pos symptoms
-However 25% patients did not show improvement, and 30-40% did not show full remission- so not full cure + demonstrates a lack of reliability
+Side effects- but lead to development of second gen antipsychotics (a-typical)
-Economic benefits
-Reductionist