sz Flashcards

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1
Q

brief summary of sz

A

Schizophrenia is the most common psychotic disorder, affecting around 1% of the population. It is often diagnosed between 15 and 35, with men and women equally affected. The symptoms are typically divided into positive and negative. To be diagnosed, 2 or more symptoms must be apparent for 1 month, as well as reduced social functioning. Type 1 schizophrenia is characterized by positive symptoms which are symptoms that reflect excess or distortion of reality.

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2
Q

what type of symptoms is type 1 associated with?

A

positive

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3
Q

explain some positive symptoms?

A

Hallucinations – unreal perceptions of the environment which are usually auditory ( hearing voices that other people cant hear but may also be visual seeing lights, objects or faces that other people cant see olfactory smelling thins that other people cant smell or tactile feeling bugs that are crawling under the skin Many SZs also report hearing voices telling them to do something.

Delusions - Firmly held erroneous beliefs that are caused by distortions of reasoning or misinterpretations of perceptions

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4
Q

what type of symptoms is type 2 associated with?

A

Type 2 schizophrenia is characterized by negative symptoms and generally has poorer prospects for recovery.

They weaken the person’s ability to cope with everyday functioning due to loss of usual abilities and experiences.

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5
Q

explain some negative symptoms?

A

Speech poverty - Distortions or exaggerations of perception in any of the senses, most notably auditory. The character signs are producing fewer words in a given time on verbal fluency tasks, and also using less complex syntax e.g shorter utterances

Avolition - Firmly held erroneous beliefs that are caused by distortions of reasoning or misinterpretations of perceptions e.g sitting in the house for hours a day doing nothing. It is a reduction in self-initiated activities that are available to them, rather than disinterest which may be due to having no social contact with family and friends because they have none.

Anhedonia – loss of interest or pleasure in all/almost all activities. E.g physical anhedonia (no pleasure from food, bodily contact), or social anhedonia (inability to experience pleasure from interacting with others.

Affective Flattering – reduced range of emotional expression, e.g facial expression, voice tone, eye contact

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6
Q

explain the two types of reliability for SZ

A

Reliability – concerns the consistency of symptom measurement and can affect diagnosis in 2 ways

Test – retest reliability – Be able to produce the same results from multiple consecutive tests for schizophrenia

Inter-rater reliability - Two or more different clinicians are making the same diagnosis of the same patient

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7
Q

evaluate reliability of SZ? and studies to evaluate with?

A

Becker et al (1961)

Looked at the inter-rater reliability between two psychiatrists when considering diagnoses for 154 patients.

Reliability was only 54% - they agreed on diagnoses for 54% of the 154 patients.

Therefore inter-rate reliability using the DSM is low as the clinicians are only agreeing on around 50%

HOWEVER inter rater reliability has gone up

Soderberg et al (2005) reported concordance of 81% with DSM

probably to do with the fact the classification systems have been updated - we are on DSM 5

inter-rater reliability has gone up

BUT Nilsson et al. (2000) only 60% concordance with ICD classification, implying

ICD appears to have worse inter-rater reliability and there seems to be differences within the classification systems

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8
Q

what are the classification systems of mental disorders?

A

Mental disorders are diagnosed by reference to a classification system, where a group of symptoms can be classed together as a syndrome.

The 2 commonly used ones are the DSM-5 (USA) and ICD-10 (WHO)

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9
Q

study that suggests SZ is as a result of environmental causes?

A

Keith et al (1991)

Looked at social class bias 
The percentages of those diagnosed with schizophrenia in: 
Lower class: 1.9% 
Middle class: 0.9% 
Upper class: 0.4% 

Johnstone claimed the lower class tend to be diagnosed more with severe disorders than middle class people with very similar symptoms.

Schizophrenia could be as a result of environmental causes

This could be because psychiatrists tend to be white and middle to upper class. They may not understand the behaviour of the lower social class patients, which leads to a problem of reliability.

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10
Q

what are the different types of validity for sz?

A

Predictive Validity – if diagnosis leads to successful treatment, then diagnosis is valid

Descriptive validity – to be valid, patients with SZ should differ in symptoms from patients with other disorders

Aetiological validity – to be valid, all SZs should have the same cause of the disorder

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11
Q

study into descriptive validity of SZ?

A

Rosenhan (1973) He arranged for ‘pseudopatients’ to present themselves to psychiatric hospitals claiming to be hearing voices (a symptom of schizophrenia). All were diagnosed with schizophrenia and admitted, despite the fact they displayed no further symptoms during their hospitalisation. Throughout their stay, none of the staff recognised that they were actually normal. They remained in hospital for an average of 19 days (ranging from 7-52 days!)

Behaviour was interpreted to meet expectations. Sanity was not recognized.

This shows that the diagnosis for SZ has problems with descriptive validity because professionals cannot recognize the difference between a genuine symptom of schizophrenia and someone who is claiming to have one.

Implications:
Legal – not guilty or guilty
Economic implications – allocation of resources

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12
Q

describe the problem of co-morbidity and SZ? what study supports this?

A

Differentiating schizophrenia from other disorders is not always easy. This is particularly the case as patients may have more than one disorder which co-occur (co-morbidity). For example, schizophrenia and depression are often found together. This affects the descriptive validity of classifying and diagnosing schizophrenia because it is hard to tell how ‘real’ and distinct an individual mental illness is.

Sim et al. (2006) reported 32% of 142 hosptialised SZs had an additional mental disorder

These findings suggest that there will be a problem with diagnosing schizophrenia- due to poor descriptive validity

Depression/schizophrenia - hard to differentiate between symptoms

Implications – need to figure out what disorder the person has before you can treat it

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13
Q

explain cultural bias of SZ? study to support this?

A

Culture bias refers to the tendancy to over diagnose members of other cultures as suffering from SZ. In Britain, people from Afro-Carribean descent are much more likely than white people to be diagnosed, and in addition psychiatrists are more likely to perceive them as being dangerous. One issue is that positive symptoms such as auditory hallucinations may be more acceptable in African cultures, and thus people are more ready to acknowledge such experiences

McGovern and Cope (1977) reported that 2 thirds of patients in Birmingham hospitals were first and second generation Afro-Carribeans, the other 3rd being white and Asian

Problem with reliability because there is no reason as to why afro Caribbean’s are more likely to have schizophrenia

This could be as a result of ethnocentrism or imposed etic

However this could be as a result of how in 1997 there may have been racism, this could be an explanation for the racial bias

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14
Q

explain gender bias in terms of SZ? study to support this?

A

Gender bias occurs in diagnosis, as men are more likely to be diagnosed than women, despite the belief that males and females are equally vulnerable. It appears that female patients typically function better than men, being more likely to work and have good family relationships (Cotton et al. 2009), this may explain why may not be diagnosed even where they have similar symptoms to men.

Loring and Powell (1988) randomly selected male and female psychiatrists to review patient cases. When patients were described as male, 56% of psychiatrists gave a diagnosis of SZ, whereas when described as female, 20% were given a diagnosis

Because we are being inconsistent with diagnosing men and women this is a problem with reliability.

BUT gender bias was not as evident amongst female psychiatrists , suggesting that the diagnosis is influenced not only by the gender of the patient but also the gender of the clinician.

This suggests that there I bias within psychiatrists

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15
Q

explain the overlap of symptoms and SZ and study to evaluate? use examples

A

There is an overlap between the symptoms of SZ and other conditions. Where conditions share many symptoms, this questions the validity of classifying to 2 disorders separately. E.g SZ and bipolar involve similar symptoms such as delusions and descriptive symptoms such as avolition. Symptom overlap can also occur with autism and cocaine intoxification.

Serper et al. (1999) assessed patients with co-morbid SZ and cocaine abuse, cocaine intoxification on its own and SZ on its own. They found that although there is in symptoms, it was possible to make accurate diagnoses.

Social anhedonia symptom overlap between schizophrenia and autism

symptom delusions overlap between schizophrenia and cocaine use.

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16
Q

what are the issues with labelling people with SZ?

A

Social prejudice – stigma attached with diagnosis

Job prospect lower – economic implications – cannot get a job – claim benefits

17
Q

what are the biological explanations for SZ?

A

Genetics

The dopamine hypothesis

18
Q

explain genetics as a biological explanation for SZ

A

The genetic explanation sees SZ as transmitted through hereditary means ,

i.e through the genes passed on by family members .

Because a number of genes appear to confer a small increased risk of SZ it appears that SZ is polygenetic i.e it requires a number of factors to work in combination.

It also appears that SZ is aetiologically heterogenous, meaning different combinations of factors can lead to the condition.

It has been found that 108 separate genetic combinations were associated with increased risk of SZ.

Commonly twin studies are also used to investigate the hereditary basis of SZ. If mz twins (who share 100% of their genes) are more concordant than DZ twins (who share only 50% of their genes), than this suggests the similarity is due to genetic factors.

19
Q

study to support genetic explanation of SZ?

A

Gottesman and Shields (1976) reviewed 5 twin studies and found concordance rates of 75% and 91% for MZ twins with severe forms of SZ

This show that schizophrenia is genetic as there is a high concordance rate in MZ twins than DZ twins

20
Q

study to evaluate the genetic explanation of SZ?

A

However

concordance rates are not 100% therefore there maybe other factors in the environment that can cause SZ for example MZ twins environmental triggers are likely to be more similar they are treated in the same way

This reinforces that the environment may be a confounding variable and that SZ is not completely biologically determined

21
Q

explain the dopamine hypothesis?

A

The dopamine hypothesis claims that an excess of the neurotransmitter dopamine in certain regions of the brain sub cortex) is associated with the positive symptoms of SZ (Hyperdopaminergia in the subcortex) Schizophrenics are thought to have abnormally high D₂ receptors on receiving dopamine resulting in more dopamine_____________ and therefore more neurons activity For example excess of dopamine receptors in Broca’s area may be associated with poverty of speech.

More recent versions of the dopamine hypothesis have focused on abnormal (low) dopamine levels in the brains cortex (Hypodopaminergia in the cortex). For example, low levels in the pre-frontal cortex responsible for thinking and decision making in the negative symptoms.

22
Q

what are neural correlates? and give some examples for SZ

A

Neural correlates are measurements of the structure or function of the brain that correlate with an experience, in this case SZ.

Avolition – loss of motivation. Motivation involves the anticipation of a reward and the ventral striatum is believed to be involved with this. Lower levels of activity in the VS are associated with negative symptoms of SZ.

Negative symptoms
Avolition – loss of motivation. Motivation involves the anticipation of a reward and the ventral striatum is believed to be involved with this. Lower levels of activity in the VS are associated with negative symptoms of SZ.

Positive symptoms
Lower activation in the superior temporal gyrus and anterior cingulated gyrus are found in those with hallucinations compared to controls.

23
Q

study to support neural correlates?

A

Dopamine agonists like amphetamines that increase levels of dopamine make SZ worse and produce SZ like symptoms in non-sufferers (Curran et al. 2004). Antipyshcotic drugs on the other hand work by reducing dopamine activity (Tauscher et al. 2014).

This supports hyperdopaminergia because increased levels of dopamine make SZ worse however this links more to the symptoms rather than the causation of SZ

However there is evidence to suggest that dopamine does not offer a complete explanation for SZ. Some genes identified by Ripke et al. (2014) code for the production of other neurotransmitters TST

Much of the attention has no turned to the role of glutamate (Moghaddam and Javitt 2012).

Boos et al. (2012) used MRI scans and found that SZ patients had decreased grey matter and cortical thinning compared to controls. TST
This offers some support for neural correlates as differences in the structure of the brain have been linked to SZ

24
Q

identify the main causes and debates of the biological explanation?

A

Cause and effect with neural correlates

We can’t identify causation for example we could assume that due to less activity passing through the central striatum or vice versa furthermore there may be a 3rd confounding variable due to correlation

Gene mapping offers the possibility of developing tests to identify high risk individuals , though this raises socially sensitive and ethical concerns – discuss in relation to determinism

Ethical concern that increase stress of known vulnerabilities maybe be the environmental trigger for the gene

The Diathesis-Stress model suggests there is a genetic vulnerability to a disorder, but this is triggered when an individual has been exposed to a stressful life event. Both of these factors are necessary for a disorder to develop. This is why not all the children with schizophrenia develop the disorder, and why the concordance rate for mental disorders for MZ twins is nothing like 100%.

25
Q

weakness of the genetic explanation?

A

Not as important as the diathesis stress model

A final weakness of the genetic explanation of schizophrenia is that it is biologically reductionist. The Genome Project has increased understanding of the complexity of the gene. Given that a much lower number of genes exist than anticipated, it is now recognised that genes have multiple functions and that many genes behaviour. Schizophrenia is a multi-factorial trait as it is the result of multiple genes and environmental factors. This suggests that the research into gene mapping is oversimplistic as schizophrenia is not due to a single gene.