Sz Flashcards
How does the DSM-II define Sz?
At least 2 or more positive symptoms for over a month
Wilks study with what, showed what?
RBANS showed high test-retest reliability
Whose study showed the unreliability of diagnosis of Sz?
Rosenhan
What did Copeland find?
Gave 134 US and 194 British psychiatrists a description of a patient. 69% of US diagnosed Sz whereas 2% UK.
Who estimated 50% comorbid depression in Sz patients?
Buckley. He also said 47% had comorbid substance abuse.
Klosterklotter assessed 489 entries to German psychiatric hospitals and found what?
Positive symptoms are more useful for diagnosis that negative ones.
Who found rates of Sz in African-Caribbeans was 8 times higher than white populations?
Harrison, suggesting misdiagnosis is a factor.
What was the first biological therapy for Sz?
ECT
Who’s study showed that ECT had lower recovery rates than those without ECT
Karagulla
What is an example of a conventional antipsychotic
Clozapine
How does an antipsychotic like Clozapine work?
They are considered dopamine antagonists, they bind to dopamine receptors, blocking their action
In terms of Dopamine what is Sz?
Too much dopamine
Name a side effect of traditional antipsychotics
Tardive dyskinesia
What did Davis do?
Found a higher relapse rate in those with a placebo.
How did Ross and Road criticise placebo studies?
Not accurate as the proportion of relapses are explained by withdrawal symptoms.