Systemic Skin Manifestations Flashcards
What is this condition and what organ/system is involved
jaundice (liver)
what is this condition and what organ/system is involved
caput medusae (liver)
what is this condition and what organ/system is involved
palmar erythema (liver)
What is this condition and what organ/system is involved
Muehrcke Nail (liver)
What is this condition and what organ/system is involved
Terry’s nail (liver)
What is this condition and what organ/system is involved
Lindsay’s nail (renal)
what is this condition and what organ/system is involved
calcinosis cutis (renal/thyroid)
What is this condition and what organ/system is involved
calciphylaxis (renal)
What is this condition and what organ/system is involved
Thyroid dermopathy (endocrine - thyroid)
What is this condition and what organ/system is involved
Cushing’s Syndrome (Endo - adrenal)
What is this condition and what organ/system is involved
Hirsutism (endo - adrenal (also PCOS))
What is this condition and what organ/system is involved
Adrenal insufficiency (Endo - adrenal)
What is this condition and what organ/system is involved
Diabetic dermopathy (endo - pancreas)
What condition is this and what organ/system is involved
Diabetic thick skin (endo - pancreas)
What condition is this and what organ/system is involved
acanthosis nigricans (endo - pancreas)
What condition is this and what organ/system is involved
Rheumatoid Arthritic Nodules
What condition is this and what organ/system is involved
Rheumatoid arthritic vasculitis
What condition is this and what organ/system is involved
systemic lupus erythematosus (rheum)
What condition is this
paget’s disease
What condition is this
inflammatory breast cancer
what condition is this
leukemia cutis
etiology of leukemia cutis
dissemination of neoplastic leukocytes into subQ, dermis, and epidermis
etiology of inflammatory breast cancer
rare, rapidly progressing, most commonly diagnosed at late stage
Etiology of Paget’s disease
intradermal carcinoma of nipple
Clinical presentation of systemic lupus erythematosus
malar rash - butterfly rash on face, spares intertriginous areas
discoid rash
vasculitis seen in 20% of pts
80% of pts have mucous involvement
etiology of rheumatoid arthritis nodules and vasculitis
presents late in disease
etiology of acanthosis nigricans
hyperinsulin state activates insulin growth receptors on keratinocytes provoking proliferation into the epidermis
etiology of diabetic thick skin
buildup of sugar alcohols in upper dermis leading to stiffening of collagen
etiology of diabetic dermopathy
may be caused by trauma, hemosiderin, melanin deposition, and change to blood vessels or dermis
etiology of adrenal insufficiency
low cortisol leading to high ACTH leading to high melanocyte stimulating hormone leading to excess melanin synthesis
Etiology of hirsutism
excessive terminal hair growth in a male pattern d/t excess adrogen sex steroid
etiology of cushing’s syndrome
hypercortisolism from endogenous or exogenous (glucocorticosteroids)
etiology of diabetic dermopathy
late manifestation of Grave’s Disease
buildup of carbs/proteins in dermis and subQ
etiology of calciphylaxis
end stage renal disease
abnormal calcification of arterioles in dermis, subQ, adipose tissue resulting in formation of fibrosis, thrombi, ischemia leading to NECROSIS
etiology of calcinosis cutis
seen with hyperparathyroidism, Ca and Ph mobilized from bone to serum and deposited in skin
etiology of Lindsay’s nails
increased concentration of melanocyte stimulating hormone
etiology of Muehrcke and Terry Nails
hypoalbuminemia and edema
etiology of palmar erythema
altered sex hormone metabolism
etiology of caput medusae
portal hypertension - blood shunted from liver to recannulated umbilical and abdominal wall veins
etiology of jaundice
bilirubin/bile salts deposit in skin (itchy) due to dysfunction in the way it is processed and excreted through the body
