Systemic Immunomodulators Flashcards

You may prefer our related Brainscape-certified flashcards:
1
Q

Name 3 TNF-Alpha inhibitors

A

Infliximab, Etanercept, Adalimumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

MOA of Apremilast (Otezla)

A

PDE4 inhibitor which increases cAMP which inhibits TNF-ā, IL17 and IL23

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

MOA of Methotrexate

A

inhibits DHF Reductase, inhibiting purine synthesis in S phase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which labs need to be monitored in MTX?

A

CBC, CMP, hep panel, preg test, HIV

Monitor CBC on week 2 and 4

Monitor LFTs in months 1 and 2

Monitor CBC/CMP Q3 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Cyclosporine MOA and side effects?

A

complex with cyclophilin to inhibit calcineurin and reduce IL2

causes you to BULK UP:

Hyper → bilirubinemia, uricemia, lipidemia, Kalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lab monitoring for cyclosporin INITIALLY

A

CBC, CMP, hep panel, preg test, quant gold, Mg2+, Uric acid, fasting lipids, UA, blood pressure initially

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Screening labs for cyclosporin

A

CBC, CMP, lipids, UA, Mg, BP monthly x2 months then q3 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Guselkumab, Tildrakizumab and Risankizumab block ____ of which interleukin?

A

block the p19 subunit of IL23 ( inhibits TH17)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which TNF alpha inhibitor is approved for kids >4 yo

A

Etanercept (enbrel)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name 3 IL17 inhibitors

Bonus: which one is different and how

A

Ixekizumab (TAltz) - Inhibits IL17a

Secukinumab (Cosentyx)- Inhibits IL17a

Brodalumab (Siliq) - inhibits IL17 receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which Biologics affect IL23? (4 total)

three of them act the same, one acts different

A

Ustekinumab (Stelara) → blocks p40 subunit common to IL12 and 23

Guselkumab (Tremfya), Tildrakizumab (Ilumya), Risankizumab (Skyrizi) - inhibit p19 subunit on IL23 only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

How does Calcipotriene work?

A

Vit D analog, decreases keratinocyte proliferation via blockage of IL2, IL6, IFN Gamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly