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Perio E2 > Systemic Health > Flashcards

Systemic Health Flashcards

1
Q

Problems with focal infection

A

Extracting teeth didn’t necessarily cure disease

People with good oral health and no infection still developed systemic diseases

People with no teeth still developed systemic diseases

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2
Q

The acute phase reaction cascade is a mechanism by which

A

Periodontitis could potentially influence systemic diseases

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3
Q

When will CRP levels go up

A

Infection
Fever
Any kind of infection or inflammation will increase CRP

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4
Q

Triggering factors —>_____—>______—>Secondary systemic reaction

A

Local reaction

Mediators

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5
Q

Triggering factors

A 
Infection
Necrosis
Surgery
Neoplasia 
Radiation
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6
Q

Local reaction

A

Macrophages
Fibroblasts
Endothelial and other cells

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7
Q

Secondary systemic reaction

A
  • Fever and leucocytosis
  • Complement activation
  • Serum glucocorticoids increased
  • Altered synthesis of acute phase proteins
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8
Q

Mediators

A

TNF-a
IL-1
IL-6
IFN-y

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9
Q

Complement components

A

Opsonization
Lysis
Chemotaxis (CTX)

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10
Q

Protease inhibitor

A

A1-macroglobulin

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11
Q

C-reactive protein

A

Opsonization

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12
Q

Fibrinogen

A

Coagulation factor

CTX

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13
Q

Plasminogen

A

Degrades blood clots

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14
Q

What defines a risk

A

Consistency of association
Strength of association
Correct time sequence
Specificity of associations

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15
Q

Specificity of associations

A

If a given factor is related to other diseases, its association with the disease is less likely to be interpreted as casual

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16
Q

Degree of exposure

A

The risk of developing the disease should be related to the degree of exposure to the factor

17
Q

Biological plausibility

A

The association must make sense in light of known biological mechanisms and pathway

18
Q

Atherosclerotic vascular diseae occurs where

A

Large to medium sized muscular and large elastic arteries

19
Q

Atherosclerotic vascular disease arteries are occluded with

A

Fibrolite day lesions termed atheromas

20
Q

Atherosclerotic vascular disease complications

A

Coronary thrombosis

Acute myocardial infarction

21
Q

Pathways that could explain link between periodontist and cardiovascular disease

A

Effect of periodontal bacteria on platelets

Invasion of endothelial cells and macrophages by periodontal bacteria

Endocrine like effects of pro-inflammatory mediators

22
Q

Only bacteria that was found in placenta

A

Only oral bacteria

23
Q

Systemic ________ are up regulated for endocrine like effects in vascular tissue. _____ and _____ are elevated in periodotnally diseased subjects

A

Pro-inflammatory mediators

CRP
Fibrinogen

24
Q

Periodontal inflammation and infection leads to

A

Bacteria endotoxin and cytokines released into systemic circulation

Increased endothelial adhesion molecules

Recruiters T cell

Arethoma developemnt

Plaque rupture

MI

25
Q

activation of peripheral monocytes and release of IL1 TNF and IL6 tells the liver

A

To releases acute phase response

(CRP Fibrinongen)

Increase coagulation

Thrombosis

MI

26
Q

P. Gingivalis can

A

Induce platelet aggregation

27
Q

Systemic pro-inflammatory mediators CRP and Fibringoen are

A

Elevated in subjects with periodontitis

28
Q

Placental tissues release ____ causing ______ in response to activation of _____

A

PGE2

Myometrial contraction

IL-1 TNF IL6

29
Q

Type I diabetes

A

Insulin depending
Destruction of pancreatic beta Cells
Hypo production of insulin
Before age 30

30
Q

Type 2 Diabetes

A

Non-insulin dependent
Target tissues dont respond to insulin
Usually occurs later in life

31
Q

Poorly controlled diabetics of both types tend to have

A

More periodontal attachment loss than non-diabetics

Perio E2 (9 decks)

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