Synthesis of RBC and blood diseases

Question 1

Erythropoietin

Answer 1

Exerts control of erythropoiesis (making erythrocytes)

Question 2

Erythropoietin release

Answer 2

Erythropoietin is released into blood by endothelial cells in the kidney

Question 3

Erythropoietin action

Answer 3

The normal small amounts of erythropoietin released makes erythrocytes at the same rate as they die

Question 4

Stage 1

Answer 4

Pro-erythroblast,

Question 5

Stage 2

Answer 5

Reticulocyte

Question 6

Stage 3

Answer 6

Erythrocyte

Question 7

Renal dialysis

Answer 7

People with kidney failure have insufficient erythropoietin

Question 8

Athletes

Answer 8

Athletes may abuse synthetic erythropoietin, which can cause blood to become too viscount, resulting in stroke, heart attack, blood clots

Question 9

Testosterone affects

Answer 9

Testosterone enhances RBC production by increasing erythropoietin

Question 10

Anemia

Answer 10

Decrease in ability to carry oxygen

Question 11

Anemia factors

Answer 11

1. Decrease in total number of erythrocytes
2. Diminished concentration of hemoglobin in erythrocytes
3. Combination of both

Question 12

Anemia causes

Answer 12

1. Dietary deficiencies in folic acid, iron, and/or b12
2. Toxic drugs or cancer causing bone marrow failure
3. Erythropoietin not released by kidney
4. Too many erythrocytes are destroyed

Question 13

Sickle cell disease

Answer 13

A genetic mutation caused sickle shaped erythrocytes in response to low oxygen levels in capillaries

Question 14

Causes of sickle cell anemia

Answer 14

1. Blockage of capillaries with tissue damage and pain

2. Destruction of deformed erythrocytes with anemia

Question 15

Polycythemia

Answer 15

More erythrocytes than normal

Question 16

Causes of Polycythemia

Answer 16

Natural adaptation to high altitude dwellers