Synteza nukleotydów Flashcards

1
Q

Jaki enzym katalizuje reakcję: rybozylo-5-fosforan -> 5-fosforybozylo-1-pirofosforan
ATP -> AMP

A

syntetaza 5-fosforybozylo-1-pirofosforanowa

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2
Q

Z jakich związków pochodzą at C w pierścieniach purynowych?

A

CO2, N10-formylotetrahydrofolian

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3
Q

Z jakich związków pochodzą at N w pierścieniach purynowych?

A

kwas asparaginowy, glicyna, glutamina

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4
Q

Jaki enzym katalizuje reakcję: IMP -> adenylobursztynian

GTP -> GDP + Pi

A

syntetaza adenylobursztynianowa

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5
Q

Jaki enzym katalizuje reakcję: adenylobursztynian -> AMP

A

liaza adenylobursztynianowa

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6
Q

Jaki enzym katalizuje reakcję: IMP -> XMP
+ H2O
NAD+ -> NADH+H+

A

dehydrogenaza IMP

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7
Q

Jaki enzym katalizuje reakcję: XMP -> GMP

ATP -> AMP + PPi

A

syntetaza GMP

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8
Q

Jaki enzym katalizuje reakcję: AMP -> IMP

H2O -> NH3

A

deaminaza AMP

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9
Q

Jaki enzym katalizuje reakcję: PRPP -> AMP

adenina -> PPi

A

APRT (fosforybozylotransferaza adeninowa)

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10
Q

Jaki enzym katalizuje reakcję: PRPP -> AMP

Hipoksantyna -> PPi

A

HGPRT (fosforybozylotransferaza hipoksantynowo-guaninowa)

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11
Q

Jaki enzym katalizuje reakcję: PRPP -> GMP

Guanina -> PPi

A

HGPRT

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12
Q

Poziom kwasu moczowego w surowicy lub osoczu mężczyzn

A

180-540 uM (3-9 mg/100 ml)

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13
Q

Poziom kwasu moczowego w surowicy lub osoczu kobiet

A

150-450 uM (2,5-7,5 mg/100 ml)

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14
Q

Ogólnoustrojowa pula kwasu moczowego w organizmie człowieka u mężczyzn

A

1200 mg

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15
Q

Ogólnoustrojowa pula kwasu moczowego w organizmie człowieka u kobiet

A

600 mg

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