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BIOCHEMIA > Biosynteza hemu > Flashcards

Biosynteza hemu Flashcards

1
Q

Jakiego kofaktora potrzebuje syntaza delta-ALA?

A

Witaminy B6

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2
Q

Jaki związek hamuje pierwszy etap biosyntezy hemu?

A

Hem, glukoza

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3
Q

Jaki enzym katalizuje reakcję: glicyna + bursztynylo-CoA -> kwas 8-aminolewulinowy?

A

syntaza delta-ALA

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4
Q

Jaki enzym katalizuje reakcję: kwas 8-aminolewulinowy -> porfobilinogen?

A

dehydrataza delta-ALA (syntaza porfobiligenowa)

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5
Q

Jaki enzym katalizuje reakcję: porfobilinogen -> hydroksymetylobilan?

A

deaminaza porfobilinogenowa

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6
Q

Jaki enzym katalizuje reakcję: hydroksymetylobilan -> uroporfirynogen III?

A

syntaza uroporfirynogenowa

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7
Q

Jaki enzym katalizuje reakcję: uroporfirynogen III -> koproporfirynogen III?

A

dekarboksylaza uroporfirynogenowa

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8
Q

Jaki enzym katalizuje reakcję: protoporfiryna IX -> hem?

A

ferrochelataza

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9
Q

Jakiego kofaktora potrzebuje ferrochelataza?

A

Fe2+

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10
Q

Jakiego kofaktora potrzebuje dehydrataza delta-ALA?

A

Zn2+

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11
Q

Inhibitor dehydratazy delta-ALA i ferrochelatazy

A

ołów

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12
Q

Gdzie zachodzi synteza hemu?

A

w szpiku kostnym i wątrobie

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13
Q

Gdzie zachodzi degradacja hemu?

A

w śledzionie i wątrobie

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14
Q

Jaki enzym katalizuje reakcję: koproporfirynogen III -> protoporfirynogen IX?

A

oksydaza koproporfirynogenowa

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15
Q

Jaki enzym katalizuje reakcję: protoporfirynogen IX -> protoporfiryna IX?

A

oksydaza protoporfirynogenowa

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16
Q

Jaka reakcja zachodzi podczas przemiany aminoketoadypinianu w kwas delta-aminolewulinowy?
Jaki enzym ją katalizuje?

A

dekarboksylacja

dehydrataza ALA

17
Q

Jakiego kofaktora potrzebuje deaminaza porfobiligenowa?

A

dipirometan

BIOCHEMIA (8 decks)

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