synpases Flashcards
how is the action potentail mainatained
-70 mv- electrical difference across membrane when neurone is at rest
Outside is more pos. than inside- membrane becomes permeable to na + k pump- protein+ atp- active transport
3na+ in – 1k+ out – 1 loss of charge
Membrane more to permeable to k+ as some k+ channels are permanently open + there are more of them- allows k+ to move out faster than Na+ move in maintaining -70mv
action potential process
-Outside of neurone is more pos. charge than inside
-depolarisation-exceeds threshold of -55mv- Na+ channels open – Na+ flood in neuron reaching +30mv
Repolarization- sodium ion channels close-k+ channels open- negative
Hyperpolarisation/refractory period– 80mv -overshoots decrease in voltage –
mexican wave throey
action potenials happen in one drection at each node of ranvier travelling along axon
all or nothin gprinciple
if a.p. doesnt exceed threshold- no a.p.
all have same volatage but may have different frequecnices if large
only responds to large stumuli
why is the refeactory period important
discrete impulses+one direction-limits amount of a.p. so you dont get overwhelmed by small changes
factors affecting conduction
axon diameter-less leakage of ions
temperature
saltatory conduction-diffuses node to node doesnt travel along whole of axon
insulative sheath-prevents ions diffucing out of axon
process in cholinergic synapse
depolarisation wave reaches presynaptic knob open ca+
vesicle carrying acetylcholine fuses wit presynaptic membrane
releases acetyl choline diffuses down concentration gradient across the cleft binding to receptors on post synaptic knob membrane
opens Na+ channel causing depolarisation
acetyl choline esterase degrades ach into acetyl and choline -
the reestablishes resting potential
neuromuscular joints
excitatory
neurone to muscle
end of response
acteyl cholin binds to receptor of muscle membrane
opposite of chloinergenic
inhibitory synapse
releases chloride ions to postsynaptic membrane -open channels
decreases neuron potentail to -80mv-no a.p.-hyperpolarisatoin after to maintian normal