Synergism And Antagonism

Question 1

Classification of drug interactions

Answer 1

Invivo

In vitro

Question 2

Pharmacodynamics and pharmacokinetics occur under

Answer 2

In vivo

Question 3

Drug synergism and antagonism occur under

Answer 3

Pharmacodynamics

Question 4

What is synergism?

Answer 4

An interaction between two or more drugs that causes the total effect of the drugs to be greater than the sum of the individual effects of each drug. A synergistic effect can be beneficial or harmful.

Question 5

Types of synergism

Answer 5

Synergism:
- Summation or Additive
- Potentiation

Question 6

What is drug antagonism?

Answer 6

An interaction between two or more drugs that have opposite effects on the body. Drug antagonism may block or reduce the effectiveness of one or more of the drugs.

Question 7

Types of Drug Antagonism

Answer 7

Physiological
Chemical
Competitive
Non-competitive

Question 8

Summation or additive synergism

Answer 8

It is a simple sum (addition) of effects, e.g., combination of agents for narcosis, that is 1 + 1 = 2

Question 9

Potentiation effect of synergism

Answer 9

Potentiation is an interaction between two or more drugs or agents resulting in a pharmacologic response greater than the sum of individual responses to each drug or agent.

Question 10

Types of competitive antagonistism

Answer 10

Equilibrium or reversible

Non-equilibrium or irreversible

Question 11

What is competitive antagonism?

Answer 11

Competition between agonist & antagonist for specific site or receptor

Question 12

What is non-equilibrium antagonism?

Answer 12

Here, the Antagonist binds to receptor with covalent bond, resulting in Irreversible blocking