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Neuro 1 > Synaptic Transmission > Flashcards

Synaptic Transmission Flashcards

1
Q

Glutamate Synthesis in astrocyte:

A 
Glutamate
(glutamine synthetase)
Glutamine
(glutaminase)
Glutamate
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2
Q

dopamine B-hydroxylase (DBH)

A

Creates: norepinephrine

Dopamine –> norepinephrine

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3
Q

amino acid decarboxylase

A

Creates: seratonin

5-hydroxytryptophan –> 5-hydroxytryptamine (seratonin)

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4
Q

choline acetyltransferase

A

Combines:
Acetylcoenzyme A + choline =
ACh

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5
Q

glutamine synthetase

A

Creates: glutamine

glutamate –> glutamine

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6
Q

glutaminase

A

Creates: glutamate

glutamine –> glutamate

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7
Q

Seratonin Synthesis

A 
Tryptophan
(tryptophan hydroxylase)
5-hydroxytryptophan
(amino acid decarboxylase)
5-hydroxytryptamine (seratonin)
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8
Q

Dopamine, Norepinephrine, Epinephrine Synthesis

A 
Tyrosine
(tyrosine hydroxylase)
dihyroxyphenylalanine (DOPA)
(DOPA-decarboxylase)
Dopamine
(dopamine B-hydroxylase, DBH)
Norepinephrine
(phenylethanolamine-N-methyl-transferase, PNMT)
Epinephrine
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9
Q

l-glutanic acid-1 decarboxylase

A

Creates: GABA

Glutamate –> GABA

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10
Q

DOPA-decarboxylase

A

Creates: dopamine

DOPA –> dopamine

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11
Q

Mechanisms terminating NT (5)

A
  1. Enzymatic degredation
  2. Reuptake transporters
  3. Autoreceptors
  4. Diffusion
  5. Glial cells
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12
Q

Gamma aminobutyric acid (GABA) Synthesis

A

glutamate
(l-glutanic acid-1 decarboxylase)
Gamma aminobutyric acid

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13
Q

tyrosine hydroxylase

A

Creates: dihyroxyphenylalanine (DOPA)

Tyrosine –> DOPA

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14
Q

acetylcholinesterase

A

(inhibited by sarin)
Creates: Acetylcoenzyme A + choline
Starts as: ACh

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15
Q

Criteria for NT (4)

A
  1. Synthesized in neuron
  2. Must be present in presynaptic t. and release must exert an action on postsynaptic
  3. Exogenous application must mimic effects
  4. Specific mechanism for removal
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16
Q

GABA transaminase (GABA-T)

A

From: GABA to glutamate

17
Q

ACh Synthesis:

A 
Glucose (glycolysis)
Pyruvate
Acetyl group + coenzyme A
Acetylcoenzyme A
Acetylcoenzyme A + choline (choline acetyltransferase)
Acetlycholine
18
Q

phenylethanolamine-N-methyl-transferase (PNMT)

A

Creates: Epinephrine

Norepinephrine –> Epinephrine

19
Q

VAMP (synaptobrevin)
syntaxin
SNAP-25
synaptotagin (p65)

A

v-SNARE, cleaved by Botulinum toxin B and tetanus toxin
t-SNARE, cleaved by Botulinum toxin C
t-SNARE, cleaved by Botulinum toxin A
May be V-SNARE, Ca sensor

20
Q

tryptophan hydroxylase

A

Creates: 5-hydroxytryptophan

tryptophan –> 5-hydroxytryptophan

Neuro 1 (6 decks)

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