Synaptic Transmission

Question 1

Metyrosine

Answer 1

Indication:HTN
MOA: Competes with NE for Tyrosine Hydroxylase-> inhbiits

Question 2

Reserpine

Answer 2

Indication: HTN
MOA: Inhibit VMAT (vesicular) uptake of monoamines leading to decreased NE

Question 3

Bretyliumm

Answer 3

Indications: V-Arrhythmia
MOA: Inhibit action potential propagation and thus calcium dependent synaptic vesicle fusion

Question 4

Cocaine

Answer 4

Indication: Analgesia in surgery
MOA: Blocks monoamine reuptake

Question 5

Amphetamine/Ephedrine

Answer 5

Indication: NArcolepsy, ADHD
MOA: Reverse monoamine reuptake transporters

Question 6

Naloxone, Naltrexone

Answer 6

Indication: Opioid overdose, dependence
MOA: Non-peptide blockers of opioid receptors in CNS

Question 7

SSRIs

Answer 7

Indication: Depression/anxiety
MOA: selective inhibition of serotonin reuptake transporters

Question 8

ACE Inhibitors

Answer 8

Indication: HTN
MOA: Inhibit peptide cleavage to form Ang II

Question 9

Phenylephrine

Answer 9

Indication: Hypotension during surgery
MOA: Agonist to adrendergic receptor

Question 10

MAO Inhibitors

Answer 10

Indication: Depression
MOA: Block cytoplasmic degradation of monoamines

Question 11

L-Dopa

Answer 11

Indication: Parkinson’s
MOA: acts as precursor for dopamine

Question 12

Carbidopa

Answer 12

Indication: Parkinson’s
MOA: Does not cross BBB and blocks L-Dopa conversion to dopamine -> protects peripheral adrenergic neurons from producing too much DA/NE

Question 13

Tyramine

Answer 13

Dietary
Competes with NE for transport into synaptic vesicle
Do NOT eat when on MAO inhbitor