Synaptic Plasticity Flashcards

1
Q

Define learning.

A

An active process that involves the extraction of meaning from sensory input by paying attention to it long enough to reach working or short-term memory.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the three basic elements of memory?

A

Encoding.
Storage.
Retrieval.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Define encoding in terms of memory.

A

Information gets into our brains in a way that allows it to be stored.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Define storage in terms of memory.

A

Information is held in a way that allows it to be retrieved later.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Define retrieval in terms of memory.

A

Information is reactivated and recalled in a form similar to what was encoded.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Name the two categories of long-term memory.

A

Declarative.
Non-declarative.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Name the two categories of declarative memory.

A

Episodic.
Semantic.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name the four categories of non-declarative memory.

A

Procedural.
Priming and perceptual learning.
Simple classical conditioning.
Non-associative learning.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is episodic memory?

A

Personal episodes in time and space.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is semantic memory?

A

Facts, meanings, concepts and knowledge about the external world.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is procedural memory?

A

Skills and habits.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Which brain regions are involved in episodic memory?

A

Hippocampus.
Medial temporal lobe.
Neocortex.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which brain regions are involved in semantic memory?

A

Lateral and anterior temporal cortex.
Prefrontal cortex.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Which brain regions are involved in procedural memory?

A

Striatum.
Cerebellum.
Motor cortex.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Which brain regions are involved in priming and perceptual learning memory?

A

Neocortex.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which brain regions are involved in simple classical conditioning memory?

A

Amygdala.
Cerebellum.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Which brain regions are involved in non-associative learning memory?

A

Reflex pathways.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Describe the two main elements of the hippocampal circuit for memory.

A

Sensory information converges in the entorhinal cortex.
The hippocampus adds contextual and temporal information.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Define anterograde amnesia.

A

An inability to form new long-term memories; short-term memory is generally intact.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Explain the Hebbian cell assembly.

A

Presentation of a stimulus activates a small network of neurons, and the connections between them are strengthened.
Partial presentation of the original stimulus activates only a subset of cells in the assembly.
Since the connections have been strengthened, the partial stimulus is sufficient to reactivate the memory.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is thought to underlie memory?

A

Changes in the strength of synaptic connections between neurons.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Define post-tetanic potentiation (PTP).

A

A transient increase in EPSP amplitude resulting from high frequency presynaptic stimulation.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What is the Theta burst stimulation protocol?

A

5 bursts of 4 pulses at 100 Hz.
The timing between bursts is designed to mimic the oscillatory patterns of brain networks.

24
Q

Where do perforant path axons originate from and where do they project to?

A

Originate from the entorhinal cortex.
Project to granule cells in the dentate gyrus.

25
Q

The synaptic activity evoked by stimulating perforant path axons was recorded extracellularly from the dentate gyrus of anaesthetised rabbits. What did high frequency stimulation result in?

A

Induced a persistent increase in the efficacy of these synapses (postsynaptic response becomes stable at a higher level than before the high frequency stimulation).

26
Q

Define coincident activation.

A

The simultaneous activation of multiple synaptic inputs or neurons.

27
Q

What are the three key properties of LTP?

A

Cooperativity.
Associativity.
Synapse specificity.

28
Q

In one sentence, describe Donald Hebb’s most famous theory.

A

Neurons that fire together wire together.

29
Q

What is metaplasticity?

A

The plasticity of synaptic plasticity.

30
Q

Describe cooperativity in terms of LTP.

A

Coincident activation of multiple weak synapses induces LTP.

31
Q

Describe associativity in terms of LTP.

A

Simultaneous activation of strong and weak synapses together induces LTP.

32
Q

Describe synapse specificity in terms of LTP.

A

Unstimulated synapses do not support the induction of LTP.

33
Q

Name the six main kinases involved in LTP.

A

PKA.
CaMKII.
PKC.
MAPK.
PTK.
PI3K.

34
Q

What is the overall role of CaMKII in LTP?

A

To enhance AMPARs and their trafficking.

35
Q

What does elevated calcium ion levels activate?

A

Calmodulin.

36
Q

What does calmodulin activate?

A

CaMKII.

37
Q

Describe the three actions of CaMKII in LTP.

A

Phosphorylates AMPA GluA1 subunits at Ser831 to enhance conductance.
Triggers exocytosis of AMPARs at extrasynaptic locations.
Phosphorylates stargazin.

38
Q

What is stargazin?

A

AMPA binding protein.

39
Q

What happens to phosphorylated stargazin?

A

Binds to PSD95, which anchors the associated AMPAR into the PSD.

40
Q

What does low frequency stimulation (LFS) induce?

A

Long-term depression (LTD).

41
Q

What two elements is LTD dependent on?

A

NMDAR activation.
Calcium influx into the postsynaptic cell.

42
Q

How does D-AP5 block induction of LTD?

A

It is an NMDAR antagonist, so it inhibits NMDAR activity.

43
Q

How does BAPTA block induction of LTD?

A

Once loaded into the postsynaptic cell, BAPTA binds to calcium and prevents it from signalling.

44
Q

How much calcium enters the postsynaptic cell when low frequency stimulation is applied?

A

Only a small amount.

45
Q

What does a small increase in intracellular calcium lead to?

A

Activates calcineurin.

46
Q

What is calcineurin?

A

Protein phosphatase.

47
Q

What is another name for calcineurin?

A

PP2B.

48
Q

What two actions does calcineurin perform?

A

Dephosphorylates Ser845 on the GluA1 subunit to constrain AMPA conductance.
Facilitates the activity of PP1 by dephosphorylating inhibitor-1.

49
Q

What is the purpose of PP1?

A

Blocks CaMKII.
Reverses the CaMKII-dependent insertion of AMPARs into the PSD resulting in LTD.

50
Q

Fill in the blanks. Low-frequency stimulation leads to ___ activation of NMDARs and ___ levels of intracellular calcium. This activates ___, leading to ___.

A

Weak.
Low.
Phosphatases.
LTD.

51
Q

Fill in the blanks. High-frequency stimulation leads to ___ activation of NMDARs and ___ levels of intracellular calcium. This activates ___, leading to ___.

A

Strong.
High.
Kinases.
LTP.

52
Q

How do LTP and LTD complement one another?

A

They both target similar induction and expression machinery.

53
Q

What is meant by frequency-dependent induction of plasticity?

A

Increasing the frequency of stimulation (and degree of NMDAR activation) shifts the balance of intracellular calcium away from protein phosphatase activation (required for LTD) to protein kinase activation (required for LTP).

54
Q

Which two factors determine the direction of plasticity?

A

Induction protocol.
Level of intracellular calcium.

55
Q

Define depotentiation.

A

A synaptic plasticity process that reverses LTP and returns a synapse to its original state, induced by LFS.

56
Q

Give an example of how treatments that target modulatory neurotransmitter systems can induce multiple forms of synaptic plasticity.

A

Blocking adenosine A1 receptors with caffeine or DPCPX in area CA2 of the hippocampus potentiates glutamate-mediated transmission.