Synapses

Question 0

Ionotropic receptor

Answer 0

Binding of neurotransmitter on region causes confirmational change - twist of subunits causing pore to open
Ion moves in to form AP in second neurone

Question 1

Two main categories of post synap neurotransmitter receptors

Answer 1

Transmitter gated ion channels (ionotropic)

Gprotein coupled receptor (metabotropic)

Question 2

Three steps for g protein coupled receptors

Answer 2

• NT binds to receptor protein in post synaptic memb
• receptor protein activates small g protein
• this activates effector proteins which can be
  ~ g protein gated ion channels in membrane
  ~ enzymes that synthesise second messenger molecules (which activate additional enzymes which can alter cell metabolism)

Question 3

Autoreceptors

Answer 3

Found in presynaptic axon terminal
Sensitive to NT and causes inhibtion of NT release and synthesis
Self regualtion
Greceptors

Question 4

Synaptic integration

Answer 4

Post synaptic neurones have many ion channels or g protein channels. So need to integrate all these EPSPs (signals) to form one AP

Question 5

2 types of summation

Answer 5

Spatial: adding of EPSPs generated simultaneously at many different synapses on a dendrite

Temporal: adding together of EPSPs from same synapse if they occur in rapid succession

Question 6

Inhibitory post synaptic potentials

Answer 6

Usually transmitter gated ion channels
GABA or glycine transmitter
Ion channels allow Cl- ions to pass in causing hyperpolarisation

Question 7

Modulation

Answer 7

Many synapses with g protein receptors that arent associated w channels
Dont evoke EPSP OR IPSPS
modify effectiveness of EPSPs of other transmitter gated channels